Journal of Clinical and Diagnostic Research, ISSN - 0973 - 709X

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Original article / research
Year : 2018 | Month : August | Volume : 12 | Issue : 8 | Page : UC06 - UC10

Comparative Evaluation of Two Different Doses of Dexmedetomidine for Tympanoplasty under Monitored Anaesthesia Care

Hemlata, Jyotsana Agarwal, Sunil Kumar Tripathi, Rajni Kapoor, Shobhana Jafa, Anita Malik, Rita Wahal, Asha Awasthi

1. Assistant Professor, Department of Anaesthesiology, King George's Medical University, Lucknow, India. 2. Professor, Department of Anaesthesiology, King George's Medical University, Lucknow, India. 3. Senior Resident, Department of Anaesthesiology, King George's Medical University, Lucknow, India. 4. Professor, Department of Anaesthesiology, King George's Medical University, Lucknow, India. 5. Professor, Department of Anaesthesiology, King George's Medical University, Lucknow, India. 6. Professor, Department of Anaesthesiology, King George's Medical University, Lucknow, India. 7. Professor, Department of Anaesthesiology, King George's Medical University, Lucknow, India. 8 Professor Cum Physicist, Department of Anaesthesiology, King George's Medical University, Lucknow, India.

Correspondence Address :
Dr. Hemlata,
Type IV/3, SGPGI Campus, Lucknow -226014, Uttar Pardesh, India.
E-mail: hema2211@yahoo.co.in

Abstract

Introduction: There are several advantages of performing tympanoplasty under Monitored Anaesthesia Care (MAC) and Dexmedetomidine is a good sedative-analgesic for MAC.

Aim: To compare the analgesic and sedative efficacy of two different loading doses of dexmedetomidine for tympanoplasty under MAC.

Materials and Methods: After taking ethical committee approval, patients were allocated into two groups of 40 each. Group I and Group II patients received injection dexmedetomidine at a loading dose of 1.0 g/kg and 0.5 g/kg respectively over 10 min followed immediately by a continuous infusion of 0.4g/kg/h. Degree of sedation and pain intensity were assessed using Ramsay Sedation Score (RSS) and Visual Analogue Scale (VAS) respectively. Total rescue doses of Fentanyl and Midazolam as well as surgeon and patient satisfaction scores (Numerical Rating Scale NRS 0-10) were noted. Student t-test, paired t-test and chi-square test were used for statistical analysis.

Results: Requirement of higher rescue doses of Fentanyl was more in Group II (100%) as compared to Group I (15.00%) (Z=61.760;p<0.001) and that of Midazolam was also more in Group II (92.50%) as compared to Group I (2.50%) (Z=65.234; p<0.001). Surgeon Satisfaction score was higher in Group I (8.750.54) than Group II (6.950.50) (Z=7.784;p<0.001). Patient Satisfaction score was also higher in Group I (8.700.56) than Group II (6.280.60) (Z=7.914;p<0.001).No postoperative complication was seen in any group.

Conclusion: A loading dose of 1 g/kg of dexmedetomidine over 10 min provides better sedation, analgesia, patient satisfaction and surgeon satisfaction than 0.5 g/kg over 10 min without causing any per-operative problem and seems to be a safe and effective primary sedative technique for tympanoplasty under MAC.

Keywords

Alpha 2-receptor agonist, Conscious sedation, Local anaesthesia, Patient satisfaction, Surgeon satisfaction

How to cite this article :

Hemlata, Jyotsana Agarwal, Sunil Kumar Tripathi, Rajni Kapoor, Shobhana Jafa, Anita Malik, et al.. COMPARATIVE EVALUATION OF TWO DIFFERENT DOSES OF DEXMEDETOMIDINE FOR TYMPANOPLASTY UNDER MONITORED ANAESTHESIA CARE. Journal of Clinical and Diagnostic Research [serial online] 2018 August [cited: 2018 Jul 16 ]; 12:UC06-UC10. Available from
http://jcdr.net/back_issues.asp?issn=0973-709x&year=2018&month=August&volume=12&issue=8&page=UC06-UC10&id=11878

DOI and Others

DOI: 10.7860/JCDR/2018/35818.11878

Date of Submission: Feb 01, 2018
Date of Peer Review: Mar 27, 2018
Date of Acceptance: May 21, 2018
Date of Publishing: Aug 01, 2018

FINANCIAL OR OTHER COMPETING INTERESTS: None.

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