Journal of Clinical and Diagnostic Research, ISSN - 0973 - 709X

Users Online : 31213

Case report
Year : 2018 | Month : February | Volume : 12 | Issue : 2 | Page : ED01 - ED03

Emphasising the Distinctive Epithelioid Morphology and Clinical Connotation of Hepatic LECT2-Associated Amyloidosis (ALECT2): A Case Report and Review of the Literature

DongHyang Kwon, Bhaskar V Kallakury

1. Resident, Department of Pathology, MedStar Georgetown University Hospital, Washington, District of Columbia, USA. 2. Professor, Department of Pathology, MedStar Georgetown University Hospital, Washington, District of Columbia, USA.

Correspondence Address :
Dr. DongHyang Kwon,
3900 Reservoir Rd., Washington, District of Columbia, USA.


Amyloidosis is a protein deposition disorder caused by pathologic accumulation of fibrils, leading to organ dysfunction. The newest protein is Leukocyte Cell-derived Chemotaxin 2 Amyloidosis (ALECT2), which shows ethnic predilection for Hispanics, Middle Eastern, and other minority groups. We report a case of 71-year-old Persian male with history of hepatitis B and resected hepatocellular carcinoma who presented with acute onset jaundice and abnormal liver function tests. Liver biopsy performed for diagnostic workup revealed hepatic ALECT2 with distinct signet-ring like globular proteinaceous deposits infiltrating hepatic parenchyma, mimicking epithelioid/histiocytic neoplasm. The infiltrative spherular material was positive for Congo red and negative for pan-keratin stains. Amyloid protein analysis by Liquid Chromatography tandem Mass Spectrometry (LC MS/MS) identified a peptide profile indicative of ALECT2. Although, ALECT2 accounts for the second most common cause of hepatic amyloidosis, only limited cases of hepatic ALECT2 are reported in the literature and little is known about patient management, especially the role of transplant as curative option. In summary, hepatic ALECT2 is an emerging disorder with relative high prevalence that deserves morphologic recognition. The report intends to emphasise distinctive morphology for accurate diagnosis and understanding its pathogenesis, clinical significance, and therapeutic strategies.


Congo red, Hepatic amyloidosis, Mass spectrometry

How to cite this article :

DongHyang Kwon, Bhaskar V Kallakury. EMPHASISING THE DISTINCTIVE EPITHELIOID MORPHOLOGY AND CLINICAL CONNOTATION OF HEPATIC LECT2-ASSOCIATED AMYLOIDOSIS (ALECT2): A CASE REPORT AND REVIEW OF THE LITERATURE. Journal of Clinical and Diagnostic Research [serial online] 2018 February [cited: 2018 Aug 20 ]; 12:ED01-ED03. Available from

DOI and Others

DOI: 10.7860/JCDR/2018/31043.11143

Date of Submission: Jun 21, 2017
Date of Peer Review: Jul 29, 2017
Date of Acceptance: Aug 21, 2017
Date of Publishing: Feb 01, 2018


JCDR is now Monthly and more widely Indexed .
  • Emerging Sources Citation Index (Web of Science, thomsonreuters)
  • Index Copernicus ICV 2016: 132.37
  • Academic Search Complete Database
  • Directory of Open Access Journals (DOAJ)
  • EBSCOhost
  • Embase & EMbiology
  • Google Scholar
  • HINARI Access to Research in Health Programme
  • Indian Science Abstracts (ISA)
  • Journal seek Database
  • Google
  • Popline (reproductive health literature)