Journal of Clinical and Diagnostic Research, ISSN - 0973 - 709X

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Original article / research
Year : 2018 | Month : July | Volume : 12 | Issue : 7 | Page : BC10 - BC13

Serum Lipoprotein (a) as a Diagnostic Marker of Coronary Artery Disease: A Case-Control Study

MM Kavitha, Jeevan G Ambekar, Sangappa V Kashinakunti, Nilima Dongre

1. PhD Scholar, Department of Biochemistry, Shri B.M. Patil Medical college, Hospital Research Centre, BLDE Deemed to be University, Vijayapura, Karnataka, India. 2. Professor, Department of Biochemistry, Shri B.M. Patil Medical College, Hospital Research Centre, BLDE Deemed to be University, Vijayapura, Karnataka, India. 3. Professor, Department of Biochemistry, S. Nijalingappa Medical College and Hanagal Sri Kumareshwara Hospital and Research Centre, Bagalkot, Karnataka, India. 4. Associate Professor, Department of Biochemistry, Shri B.M. Patil Medical College, Hospital Research Centre, BLDE Deemed to be University, Vijayapura, Karnataka, India.

Correspondence Address :
Dr. M.M. Kavitha,
Department of Biochemistry, B.M. Patil Medical College, BLDE Deemed to be University, Vijayapura-586103, Karnataka, India.
E-mail: mekch@rediffmail.com

Abstract

Introduction: Coronary Artery Disease (CAD) is a major cause of mortality in India. Conventional risk factors fail to explain the increasing burden of CAD, thus necessitating to search for newer risk factors like Lipoprotein (a) {Lp(a)}. Lp(a) is considered as one of the risk marker of CAD. Lp(a) levels have shown wide ethnic variation among human population.

Aim: The study was aimed to estimate Lp(a) levels in CAD patients and to compare it with healthy controls. To see the correlation between Lp (a) with other lipid parameters and also to find the best cut-off value for Lp(a) in CAD patients in North Karnataka population.

Materials and Methods: This was hospital based, observational, case-control study done on 120 participants, with 60 CAD patients and 60 healthy controls. Lipid profile, Lp(a) and FBS (Fasting Blood Sugar) was analysed along with anthropometric measurements. Quantitative data expressed as mean±SD. Students t-test for comparison, Pearson correlation for correlation and Receiver Operating Curve (ROC) to get the best cut-off value for Lp(a) was used.

Results: Lp(a) levels were significantly increased (p<0.001) in CAD patients compared to controls with mean values 52.34±24.87 and 16.81±3.91 respectively. Triglyceride (TG) was significantly increased (p<0.001) and High Density Lipoprotein (HDL) was significantly decreased in CAD patients. Area under the curve is >0.8 with 78% sensitivity and 86% specificity. The best cut-off value is 23.7 mg/dL. Lp(a) positively correlated with Total Cholesterol (TC), Low Density Lipoprotein cholesterol (LDL) and negatively correlated with HDL.

Conclusion: Raised Lp(a) levels is associated with an increased risk and may serve as marker of CAD. When Lp(a) is above 23.7 mg/dL. it acts as a predictor for CAD even when lipid levels are in normal range. It is better to assess the Lp(a) along with routine lipid profile in all patients with CAD in north Karnataka.

Keywords

Dyslipidemia, Low density lipoprotein variant, Risk factor

How to cite this article :

MM Kavitha, Jeevan G Ambekar, Sangappa V Kashinakunti, Nilima Dongre. SERUM LIPOPROTEIN (A) AS A DIAGNOSTIC MARKER OF CORONARY ARTERY DISEASE: A CASE-CONTROL STUDY. Journal of Clinical and Diagnostic Research [serial online] 2018 July [cited: 2018 Jul 21 ]; 12:BC10-BC13. Available from
http://jcdr.net/back_issues.asp?issn=0973-709x&year=2018&month=July&volume=12&issue=7&page=BC10-BC13&id=11774

DOI and Others

DOI: 10.7860/JCDR/2018/36832.11774

Date of Submission: Apr 17, 2018
Date of Peer Review: May 08, 2018
Date of Acceptance: Jun 02, 2018
Date of Publishing: Jul 01, 2018

FINANCIAL OR OTHER COMPETING INTERESTS: None.

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