Journal of Clinical and Diagnostic Research, ISSN - 0973 - 709X

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Original article / research
Year : 2018 | Month : July | Volume : 12 | Issue : 7 | Page : FC08 - FC11

Effect of Carica papaya Linn. Unripe and Ripe Fruit Pulp Juice in Augmenting Platelet Count in Rats: An Experimental Study

Maria Jose, Sasmi MB, Elsy MI

1. Assistant Professor, Department of Pharmacology, Jubilee Mission Medical College and Research Institute, Thrissur, Kerala, India. 2. Assistant Professor, Department of Pharmacology, Jubilee Mission Medical College and Research Institute, Thrissur, Kerala, India. 3. Professor, Department of Pharmacology, Jubilee Mission Medical College and Research Institute, Thrissur, Kerala, India.

Correspondence Address :
Dr. Sasmi MB,
Assistant Professor, Department of Pharmacology, Jubilee Mission Medical College and Research Institute,
Thrissur-680005, Kerala, India.
E-mail: sasmianuraj@gmail.com

Abstract

Introduction: Thrombocytopenia is often associated with diseases like dengue, Idiopathic Thrombocytopenic Purpura (ITP), malignancy, aplastic anaemia, drug induced thrombocytopenic purpura and haemolytic uremic syndrome. There are no effective methods to treat thrombocytopenia. Carica papaya (C. papaya) fruit pulp juice contains many constituents that can act on the bone marrow and enhance its ability to produce platelets.

Aim: To evaluate the effects of fresh Carica papaya unripe and ripe fruit pulp juice on platelet count in cyclophosphamide induced thrombocytopenic rat model.

Materials and Methods: A total of 24 male Albino Wistar rats were grouped into 'Control' (A), 'Drug control' (B), 'Papaya unripe fruit pulp' (C) and 'Papaya ripe fruit pulp' (D) groups. Thrombocytopenia was induced by three doses of cyclophosphamide (50 mg/kg body weight) given subcutaneously to Groups B, C and D from day 1 to 3. Groups C and D received Carica papaya unripe and ripe fruit pulp juice orally from day 11 to 14 respectively. Platelet count, Packed Cell Volume (PCV), Red Blood Cell (RBC) count, Alanine Aminotransferase (ALT), Aspartate Aminotransferase (AST) and serum creatinine levels was measured on day 1, 10, 14 and 21. For comparison between groups, ‘unpaired t-test’ and within the group, paired t-test were used. A p-value =0.05 was considered significant.

Results: There was significant increase in platelet count in Group C (6.27×105/µL) and D (20.5×105/µL) compared to drug control B (3.94×105/µL) on day 14. Within the group, there was significant increase in platelet count in Group C and D on day 14 compared to day 10. Between the groups, Group D showed higher platelet increasing effect on thrombocytopenic rats.

Conclusion: Carica papaya ripe and unripe fruit pulp juice has platelet enhancing effect. Further preclinical studies are required to identify those chemicals of C. papaya fruit responsible for boosting thrombopoiesis.

Keywords

Cyclophosphamide, Dengue, Thrombocytopenic model

How to cite this article :

Maria Jose, Sasmi MB, Elsy MI. EFFECT OF CARICA PAPAYA LINN. UNRIPE AND RIPE FRUIT PULP JUICE IN AUGMENTING PLATELET COUNT IN RATS: AN EXPERIMENTAL STUDY. Journal of Clinical and Diagnostic Research [serial online] 2018 July [cited: 2018 Jul 18 ]; 12:FC08-FC11. Available from
http://jcdr.net/back_issues.asp?issn=0973-709x&year=2018&month=July&volume=12&issue=7&page=FC08-FC11&id=11809

DOI and Others

DOI: 10.7860/JCDR/2018/35470.11809

Date of Submission: Jan 06, 2018
Date of Peer Review: Mar 07, 2018
Date of Acceptance: May 07, 2018
Date of Publishing: Jul 01, 2018

FINANCIAL OR OTHER COMPETING INTERESTS: None.

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