Journal of Clinical and Diagnostic Research, ISSN - 0973 - 709X

Users Online : 18205

Case report
Year : 2018 | Month : July | Volume : 12 | Issue : 7 | Page : ND01 - ND03

Effective Treatment of Epithelial Downgrowth in Persistent Wound Leak Following Removal of Silicone Oil

Mae-Lynn Catherine Bastion, Kong Yong Then, Aida Mohd Zahidin

1. Professor, Department of Ophthalmology, Faculty of Medicine, UKM Medical Centre, Universiti Kebangsaan Malaysia, Malaysia. 2. Consultant Ophthalmologist, International Eye Specialist Centre, Malaysia. 3. Consultant Ophthalmologist, Department of Ophthalmology, Universiti Kebangsaan Malaysia, Malaysia.

Correspondence Address :
Dr. Mae-Lynn Catherine Bastion,
Professor, Department of Ophthalmology, Faculty of Medicine, UKM Medical Centre,
Jalan Yaacob Latif-56000, Kuala Lumpur, Malaysia.


This case report aims to share the successful management of Epithelial Downgrowth (ED) which occurred following persistent wound leak, after Removal of Silicone Oil (ROSO) via the anterior chamber. A teenage male with history of high myopia underwent bilateral phacoemulsification and implantation of Multifocal Intraocular Lens (MFIOLs). Four months later, he complained of left eye floaters and blurring of vision. Fundus showed left vitreous haemorrhage with lens subluxation. Left 23 gauge pars plana vitrectomy revealed multiple retinal tears. Endolaser and gas injection with MFIOL repositioning was done. Retinal redetachment and MFIOL subluxation occurred six weeks postoperatively. Revision vitrectomy with silicone oil and explantation of MFIOL was performed rendering left eye aphakic. Four months later, he underwent ROSO via a superior corneal incision. Positive Seidels was seen two weeks post-ROSO and resuturing was performed. Unfortunately, advancing ED was noted at the superior cornea. One month after ROSO, scleral fixated IOL implantation with manual removal of ED and intracameral injection of 5-fluorouracil (5-FU) were performed. Twelve months postoperatively, cornea remained clear with a pinhole vision of 6/7.5 and retina was flat. In conclusion, wound leak after ROSO via the anterior chamber in aphakic individuals may predispose to ED. Key to treatment of this sight threatening condition is thoughtful anterior segment examination. Manual removal of the membrane combined with 5-FU injection during secondary lens implantation surgery is an effective treatment.


Cornea epithelial downgrowth, 5-fluorouracil, Retinal redetachment

How to cite this article :

Mae-Lynn Catherine Bastion, Kong Yong Then, Aida Mohd Zahidin. EFFECTIVE TREATMENT OF EPITHELIAL DOWNGROWTH IN PERSISTENT WOUND LEAK FOLLOWING REMOVAL OF SILICONE OIL. Journal of Clinical and Diagnostic Research [serial online] 2018 July [cited: 2018 Jul 23 ]; 12:ND01-ND03. Available from

DOI and Others

DOI: 10.7860/JCDR/2018/36315.11780

Date of Submission: Mar 12, 2018
Date of Peer Review: May 03, 2018
Date of Acceptance: Jun 04, 2018
Date of Publishing: Jul 01, 2018


JCDR is now Monthly and more widely Indexed .
  • Emerging Sources Citation Index (Web of Science, thomsonreuters)
  • Index Copernicus ICV 2016: 132.37
  • Academic Search Complete Database
  • Directory of Open Access Journals (DOAJ)
  • EBSCOhost
  • Embase & EMbiology
  • Google Scholar
  • HINARI Access to Research in Health Programme
  • Indian Science Abstracts (ISA)
  • Journal seek Database
  • Google
  • Popline (reproductive health literature)