Journal of Clinical and Diagnostic Research, ISSN - 0973 - 709X

Users Online : 8686

Original article / research
Year : 2018 | Month : July | Volume : 12 | Issue : 7 | Page : UC06 - UC10

Labour Epidural Analgesia: A Randomised Double Blind Comparative Study of 0.1% Levobupivacaine with Fentanyl vs. 0.1% Ropivacaine with Fentanyl

Debasmita Das, Deepali Pankaj Thakur, Bharati Anil Tendolkar

1. Resident, Department of Anaesthesia, Lokmanya Tilak Municipal Medical College and General Hospital, Sion, Mumbai, Maharashtra, India. 2. Associate Professor, Department of Anaesthesia, Lokmanya Tilak Municipal Medical College and General Hospital, Sion, Mumbai, Maharashtra, India. 3. Professor and Head, Department of Anaesthesia, Lokmanya Tilak Municipal Medical College and General Hospital, Sion, Mumbai, Maharashtra, India.

Correspondence Address :
Dr. Deepali Pankaj Thakur,
Mount Alps B wing 606, Bhakti Park, Wadala, Mumbai-400037, Maharashtra, India.
E-mail: deepshna@rediffmail.com

Abstract

Introduction: Levobupivacaine and ropivacaine are suitable alternatives to bupivacaine for labour analgesia as they produce less motor blockade, decreased incidence of instrumental deliveries and less toxicity.

Aim: To study the efficacy of epidural levobupivacaine and ropivacaine in intermittent doses for labour analgesia.

Materials and Methods: In the present prospective, randomised, double blind study, 60 parturients consenting for labour epidural analgesia using intermittent top-up technique were randomly allocated to receive either levobupivacaine 0.1% with Fentanyl 2 mcg/mL (LF) or ropivacaine 0.1% with Fentanyl 2 mcg/mL (RF). Haemodynamic parameters, sedation score, onset and quality of analgesia, sensory and motor blockade, local anaesthetic requirement, side effects, duration of labour, mode of delivery, neonatal outcome and maternal satisfaction were compared between groups. Statistical analysis included students unpaired t-test, chi-square test, Fischerís-exact test, Mann-Whitney U-test as appropriate with p<0.05 was considered statistically significant.

Results: Demographic and obstetric parameters were comparable in two groups. Both drugs were comparable with respect to haemodynamics, sedation score, onset and quality of analgesia, sensory and motor blockade, local anaesthetic requirement, duration of labour, mode of delivery, neonatal outcome, maternal satisfaction and side effects. One parturient (3.33%) in RF group developed motor block of Bromage grade 1 as compared to none in LF group without any statistical significance. No parturient required Rescue analgesia.

Conclusion: The combinations of low concentration (0.1%) of epidural levobupivacaine and ropivacaine with fentanyl provide equivalent labour analgesia, without significant maternal or fetal side effects.

Keywords

Anaesthetic drugs, Low concentration local anaesthetics, Opioids

How to cite this article :

Debasmita Das, Deepali Pankaj Thakur, Bharati Anil Tendolkar. LABOUR EPIDURAL ANALGESIA: A RANDOMISED DOUBLE BLIND COMPARATIVE STUDY OF 0.1% LEVOBUPIVACAINE WITH FENTANYL VS. 0.1% ROPIVACAINE WITH FENTANYL. Journal of Clinical and Diagnostic Research [serial online] 2018 July [cited: 2018 Jul 21 ]; 12:UC06-UC10. Available from
http://jcdr.net/back_issues.asp?issn=0973-709x&year=2018&month=July&volume=12&issue=7&page=UC06-UC10&id=11769

DOI and Others

DOI: 10.7860/JCDR/2018/31764.11769

Date of Submission: Jul 24, 2017
Date of Peer Review: Sep 14, 2017
Date of Acceptance: Feb 20, 2018
Date of Publishing: Jul 01, 2018

FINANCIAL OR OTHER COMPETING INTERESTS: NONE.

JCDR is now Monthly and more widely Indexed .
  • Emerging Sources Citation Index (Web of Science, thomsonreuters)
  • Index Copernicus ICV 2016: 132.37
  • SCOPUS
  • Academic Search Complete Database
  • Directory of Open Access Journals (DOAJ)
  • EBSCOhost
  • Embase & EMbiology
  • Google Scholar
  • HINARI Access to Research in Health Programme
  • Indian Science Abstracts (ISA)
  • Journal seek Database
  • Google
  • Popline (reproductive health literature)
  • www.omnimedicalsearch.com