Proliferative
Indices, Ki-67 Immunostaining
and Nucleolar Organizer Region Associated
Protein and their Association with Various
Grades of Breast Carcinomas
1371-1374
Correspondence
Dr. Manisha Sharma, C/O Mr S. L Sharma
B-241, Ranjit Avenue, Amritsar-143001
Punjab, India.
Phone: +919876842942
E-mail: manisha_salwan@yahoo.com
Introduction: Clinical outcome of the tumour in many cases is related with cell proliferation which can be detected by mitotic figure counts, AgNOR counts and most promising approach of immunohistochemical (IHC) assessment of Ki-67.
Material and Methods: The present study was conducted on 40 specimens of breast carcinoma out of which 12 cases were of Grade II and 28 cases were of Grade III. Percentage positivity and scoring of Ki-67 and mean AgNOR count was done with relation to grades.
Observations: Ki-67 positivity was seen in 12 cases with the percentage positivity of 2.33±5.516 in grade II and 9.67±7.671 in grade III tumours . Similarly Mean AgNOR count in grade II was 3.39±0.79 and 4.28±1.07 in grade III cases. Mean Ki-67 positivity was 7.2% in cases showing metastatic deposits and it was 6.3% in cases with reactive pathology in lymph nodes.
Conclusion: It is concluded that Ki-67 positivity and AgNOR count increases with the increase in the grade of carcinoma breast and metastasis in lymph node. Therefore, Ki-67 expression and high mean AgNOR count can be associated with poor prognosis in carcinoma breast.