Detection Of Human Papilloma Virus In Esophageal Squamous Cell Carcinoma In Guilan Province
2373-2377
Correspondence
Seyed Mohammad Mohseni Mehran (PhD)
Department of Physiology,Rasht Medical School
Guilan University of Medical Sciences,Rasht, (Iran)
Tel: +981316690099,Fax: +981316690007
Email: mohsenimehran@gums.ac.ir
Background: Despite many researches on the causes of Esophageal Squamous Cell Carcinoma (ESCC) many factors can cause but some types of HPV seem to be one of those factor. At the last studies the HPV cause 10 to 67% in some regions. Guilan is a region in Iran with high incidence of (ESCC) so it’s need to study more on (ESCC).
Methods: In this study, we compared the prevalence of 3 kind of primers: general markers GP5+/GP6+ to show how much HPV are participated, mild oncogenic types of HPV 31,33,35,39,41,51,52 and high-risk oncogenic types of HPV 16 and 18 on E6/E7 gene in tumor tissues from 45 ESCC cases.
Results: In 17 of 45 ESCC (37.7%) samples were positive for general markers ,GP5+/GP6+, the HPV presence was 4 of 45 and in respect of ESCC (8.8%) samples were positive for oncogenic types and 2 of the ESCC (4.4%) samples were high risk HPV 16,18 E6/E7 gene and the 22 samples were negative for HPV types.
Conclusions: Our data are consisted with HPV DNA studies conducted in high–risk area (Guilan) for ESCC. HPV should be considered as a potential factor responsible for the increased incidence of ESCC, in spite of low incident in our study in Guilan .