Role of Biochemical Investigations and Diagnostic Tools in Detection of Adverse Drug Reactions
HC23-HC26
Correspondence
Dr. Vishal R Tandon,
Assistant Professor, In-charge ADRM centre (Under PvPI)
Postgraduate, Department of Pharmacology and Therapeutics,
Govt. Medical College Jammu- J&K - 180001, India.
Phone : 09419195126, E-mail : dr_vishaltandon@yahoo.com
Aim of Study: To evaluate the role of biochemical investigations (BI) and diagnostic tools (DT) in ADR detection.
Materials and Methods: An observational prospective cross-sectional study was done using suspected ADR data collection form.
Results: A total of 2381 ADR related events were recorded in two years. Total number/percentage of biochemical abnormalities (BA) related ADR detection rate was 14.57% and of DT was 1.091% in contrast to 84.33% recorded with clinical presentation. Maximum cases were inward patients (87.13%), 67.02% were recorded by active surveillance. ADR detection rate at one point & detection on follow up was 56.31% Vs 46.38%. ADR detection rate of ECG, endoscopy, X-ray were 0.57%, 0.22%, 0.22% and of CT scan, MRI, DEXA scan, USG and biopsy was 0.04% each. Maximum ADRs were severe/serious, latent and Type-A in nature. Anemia (4.6%), followed by liver dysfunction (2.8%), renal dysfunction, electrolyte imbalance, hyperglycemia (1.1% each), abnormal coagulation profile (1%), decrease platelet count (0.8%), hypoglycemia (0.7%) were the most common BAs. Anti retroviral drugs (ART), tirofiban and methotrexate accounted for anemia, ART and anti tubercular drugs for liver & renal dysfunction, insulin for hypoglycemia, tirofiban, paclitaxel, capecipabine and ifosfamide for thrombocytopenia, hematuria by enoxaparin & dyslipidemia with ART were common ADRs.
Conclusion: BI and DT can play very important role in ADR detection.