Impact of Long versus Short Duration Diabetes on Sensory Nerve Conduction Velocity in Type 2 Diabetes Mellitus CC17-CC20
Dr. Amina Sultan Zaidi,
A1-E Vatika Apartment, Central Government Quarters, Mayapuri-110064, New Delhi, India.
Introduction: Diabetes is a metabolic disorder with debilitating complications which affects several million people worldwide. Neuropathy is the most common chronic complication of Type 2 Diabetes Mellitus (T2DM). Diagnosing peripheral neuropathy at subclinical stage and knowing the effect of duration of diabetes in it is important. Study of Sensory Nerve Conduction Velocity (SNCV) can help us to diagnose this problem at an early stage.
Aim: To determine the correlation of duration of diabetes with SNCV of Median, Ulnar, Superficial Peroneal and Sural nerves.
Materials and Methods: The present cross-sectional study was conducted in Department of Physiology, in collaboration with Rajeev Gandhi Centre for Diabetes and Endocrinology on patients of T2DM attending Diabetes clinic in Jawaharlal Nehru Medical College and Hospital (JNMCH) from 2014 to 2016 after approval from the Ethical Committee of JNMC. A total of 90 subjects were taken; among them 60 subjects were diagnosed cases T2DM, which were further divided in two groups on the basis of duration of diabetes. Rest 30 subjects were non-diabetic control group. SNCV study was done for assessing peripheral neuropathy. Statistical analysis was performed using SPSS version 21.0. One way ANOVA with Post-Hoc Tukey test were used for comparison of means between three groups. The association between continuous variables was tested by linear correlation using Pearson’s coefficient.
Results: In shorter duration of diabetes (3.31±1.72 years T2DM), significant (p<0.05) negative correlation was seen between duration of diabetes and SNCV of Median, Superficial Peroneal and Sural nerves, while in longer duration of Diabetes (12±4.42 years T2DM), there was significant (p<0.05) negative correlation between duration of diabetes and SNCV of all four nerves; namely Median, Ulnar, Superficial Peroneal and Sural.
Conclusion: Chronic hyperglycaemia in diabetes leads to the degeneration and damage of peripheral nerves.