A Case of Immunotactoid Glomerulopathy in a Patient with Multiple Myeloma OD12-OD13
Dr. Irina Rekhtina,
Leader Research Scientist, Department of Nephrology, National Research Center for Hematology of the Ministry of
Healthcare of the Russian Federation, Moscow. 125167 Novi Zikovski pr. 4, Moscow, Russia.
Cases of Immunotactoid Glomerulopathy (ITG) in patients with Multiple Myeloma (MM) are extremely rare. Consequently, data on efficacy and therapy results are limited. We report on a rare case of long-term follow-up patient with MM and ITG. After chemotherapy the patient achieved complete remission with complete recovery of renal function. A repeat renal biopsy revealed complete resorption of the deposits. After 4 years, ITG was diagnosed again in another kidney biopsy during a relapse of MM. There was excessive glomerular infiltration by lymphoid cells and obstruction of capillary lumen was identified. Bundles of microtubules, similar to the deposits in kidneys, were revealed in some lymphoid cells.