Variations in Levels of Intercellular Adhesion Molecule-1 with Disease Course in Rheumatoid Arthritis Patients OC18-OC21
Dr. Vijaya Jawahar Sarithala,
No 8/2, Morozova Street, Stavropol, 355017, Russia.
Introduction: Adhesion molecules play an important role in the migration of leukocytes, process of inflammation and in remodeling of tissue. Intercellular Adhesion Molecule-1 (ICAM-1) is expressed along the luminal, intercellular, and subluminal surface of endothelial cells and their expression increases after stimulation by cytokines and TNF-a in Rheumatoid Arthritis (RA).
Aim: To study the serum concentration of ICAM-1 in patients with rheumatoid arthritis.
Materials and Methods: Levels of ICAM-1 in 134 patients with rheumatoid arthritis (30 male, 104 female) aged 20 to 66 years were studied. Control group constituted of 70 healthy individuals of age 22 to 55 years. Concentration of ICAM-1 was determined by ELISA. Statistical analysis of the data was performed using two sample Student’s t-criterion, criteria of Newman-Keuls and correlation n analysis with application of Pearson (r) and Spearman (rs) criteria.
Results: Index DAS28 scored up to 5.49 (4.88-6.01) in the patients. Most of the patients were diagnosed with III x-ray stage, II and III functional class of the disease. In patients with rheumatoid arthritis significantly increased (p<0.05) concentration of ICAM-1 were observed when compared to controls. Increased concentrations of ICAM-1 were not related to the sex of the patient, presence or absence of rheumatoid factor and antibody to the cyclic citrullinated peptide. In patients with late clinical stage of the disease indicators of adhesion molecules were more (p<0.05) than those of early or progressive stage of the disease. In cases with highly active inflammatory process, by index DAS 28, serum levels of ICAM-1 were relatively higher (p<0.05) than in moderate activity of the disease. Values of intercellular adhesion molecules were independent of severity of x-ray stage including that of presence or absence of erosions and were not correlated with the functional class of rheumatoid arthritis. Presence of systemic effects of the disease was characterised by high serum concentrations of ICAM-1. The appearance of complications had no effect on adhesion dynamics. In patients with thrombocytosis, indicators of adhesion molecules were higher (p<0.05) than in patients with the normal range of thrombocytes.
Conclusion: In rheumatoid arthritis increased serum concentrations of (ICAM-1) were observed, mostly expressed in the form of high activity of inflammatory process and the presence of systemic effects, which shows pathological significance of adhesion molecules and progression of the disease.