Serum Creatine Kinase Activity among Hypertensive Patients and its Role as a Predictor for Failure of Antihypertensive Treatment BC19-BC22
Dr. Jyotirmayee Bahinipati,
Associate Professor, Department of Biochemistry KIMS, Patia, Bhubaneswar-751016, Odisha, India.
Introduction: Creatine Kinase (CK), a key enzyme of cellular energy metabolism helps the cells to function under high demands by involving in contractile processes and active trans-membrane transport by readily providing Adenosine-5’-triphosphate (ATP). Higher CK activity increases cardiovascular trophic responses and development of arterial hypertension. Hence, high CK activity may increase hypertension risk and may also be a cause behind the hypertensive treatment failure.
Aim: In the present study, serum CK levels are compared between hypertensive and normotensive study subjects and association of serum CK in hypertensive treatment failure cases.
Materials and Methods: A total of 75 known hypertensive patients who were under antihypertensive treatment for =3 months were taken as cases. Further grouping of the patients was done based upon the response to antihypertensive treatment into treatment control (n=40) and without treatment control (n=35) groups. Forty individuals age and sex matched normotensive control were taken. Serum Creatine Kinase, BMI, Systolic Blood Pressure, Diastolic Blood Pressure, was measured in the study group. Kruskal Wallis test was done to compare the parameters in all the three study groups. Correlation of serum CK with other parameters was done. Cut-Off value for serum CK was calculated in hypertensive cases.
Results: CK was found to be higher in hypertensive cases with treatment control (99.55±31.34) U/L compared to normotensives (72.66±25.42) U/L. Significantly higher CK level was found in hypertensive treatment failures (313.92±133.12) U/L compared to treatment control cases. Statistically significant correlation was found between serum CK with SBP and DBP in hypertensive treatment failure cases. A cut-off value of 168.5 U/L was found out in hypertensive patients.
Conclusion: Serum CK was found to be associated with severity of blood pressure and failure of antihypertensive therapy.