High-Sensitivity C-Reactive Protein and 24-Hours Ambulatory Blood Pressure Variability in Type 2 Diabetes Mellitus Patients OC04-OC07
Dr. Y Chethan,
Room No. 144, Vivek Hostel, Vidya Nagar, Hubballi-580021, Karnataka, India.
Introduction: The association between C-Reactive Protein (CRP) and cardiovascular events with hypertension being the risk factor has been studied extensively and correlated with the end-organ damage. Blood pressure variability has been linked to target organ damage and cardiovascular outcome irrespective of severity of hypertension.
Aim: To understand the correlation between hs CRP, blood pressure variability during 24-hours ABPM in Type 2 Diabetes Mellitus (T2DM) compared to control subjects.
Materials and Methods: The case-control study included data from T2DM patients with HTN (n=50), and healthy controls (n=50). Hs-CRP was assessed using Enzyme-Linked Immunosorbent Assay (ELISA) technique. All subjects underwent 24-hour ambulatory Blood Pressure (BP) monitoring; BP variability was calculated using standard deviation.
Results: Among cases there was significant positive correlation between Hs-CRP, Systolic BP (SBP) Variability, Diastolic BP (DBP) Variability and Duration of DM i.e., with increase in Hs-CRP, there was significant increase in SBP Variability, DBP Variability and Duration of DM and vice-versa. Among controls there was significant negative correlation between Hs-CRP, SBP, SBP Variability and BMI i.e., with increase in Hs-CRP, there was significant decrease in SBP, SBP Variability and BMI and vice-versa.
Conclusion: Hs-CRP is associated with 24-hour SBP variability, 24-hour diastolic BP variability and duration of T2DM. Blood pressure variability was independent predictors for Hs-CRP. The highest Hs-CRP levels were detected in T2DM patients and high BP variability.