
Anterior Segment Optical Coherence Tomography in Pseudoexfoliation Syndrome: A Cross-sectional Study
NC01-NC05
Correspondence
Dr. Krishnagopal Srikanth,
Professor and Head, Department of Ophthalmology, Mahatma Gandhi Medical College and Research Institute, Sri Balaji Vidyapeeth, Cuddalore Road, ECR, Pillayarkuppam, Puducherry-607402, India.
E-mail: kskanth99@rediffmail.com
Introduction: Pseudoexfoliation Syndrome (PXS) is a common age-related disorder of the extracellular matrix characterised by the progressive accumulation and deposition of abnormal extracellular fibrillar and Pseudoexfoliative (PXF) material in ocular and systemic tissues. Ocular involvement is generally bilateral and may be asymmetric, inducing changes in the anterior segment of the eye, particularly in the angle structures.
Aim: To study the Anterior Chamber Angle (ACA) parameters using Anterior Segment Optical Coherence Tomography (AS-OCT) in patients diagnosed with Pseudoexfoliation Syndrome (PXS).
Materials and Methods: This cross-sectional observational study was conducted at the Department of Ophthalmology, Mahatma Gandhi Medical College and Research Institute, Sri Balaji Vidyapeeth, Puducherry, India between January 2023 and July 2024. Atotal of 51 patients with evidence of pseudoexfoliative material at the pupillary border or on the anterior lens capsule in one or both eyes were included in the study. All these patients underwent a detailed ophthalmic examination, including gonioscopy and AS-OCTof the nasal and temporal angles. The Angle Opening Distance (AOD) at 500 μm, the Trabecular Iris Space Area (TISA) at 500 μm and the Trabecular Iris Angle (TIA) at 500 μm were measured from the AS-OCTimages. The angle parameters obtained from AS-OCTwere compared with the gonioscopy parameters. Appropriate statistical tests, including descriptive statistics, the post-hoc test and the one-sample t-test, were performed, with a p-value of <0.05 considered statistically significant.
Results: Atotal of 51 patients with PXSparticipated in the study. The mean age was 65.3±6.8 years. The mean AOD500 was 386.9±93.7 μm, the mean TISA500 was 0.13±0.02 mm2 and the mean TIA500 was 29.2±5.2°. AS-OCT-measured angle parameters in PXSeyes were found to be significantly reduced. All three AS-OCTparameters correlated well with gonioscopy.
Conclusion: Patients with PXSshowed narrower ACAparameters—AOD, TISAand TIA—as measured by AS-OCT. The AS-OCTparameters correlated well with the findings from gonioscopy.