Case report
Vocal Cord Amyloidosis in a Middle-aged Female: A Rare Clinical Entity
MD01-MD03
Correspondence
Dr. Pragati Shikha,
Junior Resident, Department of Otorhinolaryngology and Head and Neck Surgery, Jawahar Lal Nehru Medical College, Datta Meghe Institute of Higher Education and Research, Wardha, Maharashtra, India.
E-mail: pragati.shikha2103@gmail.com
Primary laryngeal amyloidosis is a rare disorder, accounting for approximately 1% of all benign laryngeal lesions. The authors, here, report the case of a 55-year-old female who presented to the Otorhinolaryngology Department with complaints of change in voice for the past 2-3 years. The patient described a gradual onset of hoarseness, strained quality, and fatigue of voice. Additionally, she experienced quivering, effortful phonation, and a relatively high pitch. Video-directed laryngoscopy revealed a polypoid or polypoid-like, reddish growth over the true vocal cords. A Contrast-Enhanced Computed Tomography (CECT) scan of the neck showed features suggestive of glottic and subglottic stenosis. The patient subsequently underwent microlaryngoscopy under general anaesthesia, and a unilateral excisional biopsy was taken from the lesion. Histopathological examination of a 20× section demonstrated Congo red positivity under polarised light, confirming the presence of amyloid deposits. A corresponding Haematoxylin and Eosin (H&E)-stained section (20×) showed proliferation of fibroblasts arranged in fascicles with areas of hyaline degeneration. Postoperatively, the patient was advised speech therapy, and at three weeks of follow-up, significant improvement in voice quality was noted. The present case highlights the rarity of primary laryngeal amyloidosis and underscores the importance of considering this diagnosis in patients presenting with long-standing hoarseness of voice. A multidisciplinary approach, including surgical excision, postoperative speech therapy, and long-term follow-up, is essential for achieving favourable outcomes and reducing recurrence rates.