Hypovitaminosis D is Associated with Gestational Diabetes Mellitus
Published: October 1, 2017 | DOI: https://doi.org/10.7860/JCDR/2017/27433.10691
Arijit Debnath, Mamta Gupta, Sanjay Jain, SupriyaKumari,
Tamoghna Biswas, Somosri Ray, Santosh Kumar Gupta
1. Clinical Tutor, Department of Obstetrics and Gynaecology, College of Medicine and JNM Hospital, Kolkata, West Bengal, India.
2. Senior Consultant and Head, Department of Obstetrics and Gynaecology, Hindu Rao Hospital and associated NDMC Medical College, Delhi, India.
3. Senior Specialist, Department of Microbiology, Hindu Rao Hospital and Associated NDMC Medical College, Delhi, India.
4. DNB trainee, Department of Obstetrics and Gynaecology, Hindu Rao Hospital and associated NDMC Medical College, Delhi, India.
5. MD trainee, Department of Paediatrics, Medical College, Kolkata, West Bengal, India.
6. Assistant Professor, Department of Neonatology, Medical College, Kolkata, West Bengal, India.
7. Professor, Department of Biochemistry, Maulana Azad Medical College, Delhi, India.
Correspondence
Dr. Mamta Gupta,
A-18, Greenview Aptt., Sector 9, Rohini-110085, Delhi, India.
E-mail: write2mamta55@gmail.com
Introduction: Vitamin D deficiency has been shown to cause expression of insulin gene resulting in high insulin synthesis and secretion. It also decreases insulin resistance, thus affecting abnormal glucose metabolism and diabetes.
Aim: To estimate total 25-hydroxy vitamin D levels in pregnant women and to find its association with Gestational Diabetes Mellitus (GDM).
Materials and Methods: Fifty-four antenatal women were randomly enrolled at 24-28 weeks gestation after conforming to exclusion criteria. Serum vitamin D, two-hour 75 grams glucose and postprandial plasma glucose levels were estimated in all women at the time of enrollment. GDM was diagnosed with plasma glucose level >140 mg/dL (Group A). Rest of the women constituted Group B or control group. They were followed up till delivery. Vitamin D status and fetomaternal outcome was evaluated.
Results: Hypovitaminosis D was found in 93% of women. There were 38.8% women (n=21) in GDM group compared to 61.2% (n=33) in control group. Vitamin D was significantly low in Group A than B (p-value 0.004). None of the women in Group A had vitamin D levels of 10 ng/mL and above compared to 37.2% in Group B. Severe vitamin D deficient women (levels <5 ng/mL) had a risk ratio of 5.647 for developing GDM. A negative correlation was observed between vitamin D levels and plasma glucose levels.
Conclusion: Hypovitaminosis D was associated with development of GDM.
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