Journal of Clinical and Diagnostic Research, ISSN - 0973 - 709X

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Thanking you
With sincere regards
Dr. Rajendra Kumar Ghritlaharey, M.S., M. Ch., FAIS
Associate Professor,
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Kamla Nehru & Hamidia Hospitals Bhopal, Madhya Pradesh 462 001 (India)
On May 11,2011

Dr. Shankar P.R.

"On looking back through my Gmail archives after being requested by the journal to write a short editorial about my experiences of publishing with the Journal of Clinical and Diagnostic Research (JCDR), I came across an e-mail from Dr. Hemant Jain, Editor, in March 2007, which introduced the new electronic journal. The main features of the journal which were outlined in the e-mail were extensive author support, cash rewards, the peer review process, and other salient features of the journal.
Over a span of over four years, we (I and my colleagues) have published around 25 articles in the journal. In this editorial, I plan to briefly discuss my experiences of publishing with JCDR and the strengths of the journal and to finally address the areas for improvement.
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Most of the manuscripts are published within 3 to 4 months of their submission if they are found to be suitable after the review process. JCDR is published bimonthly and the accepted articles were usually published in the next issue. Recently, due to the increased volume of the submissions, the review process has become slower and it ?? Section can take from 4 to 6 months for the articles to be reviewed. The journal has an extensive author support system and it has recently introduced a paid expedited review process. The journal also mentions the average time for processing the manuscript under different submission systems - regular submission and expedited review.
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Dr. P. Ravi Shankar
KIST Medical College, P.O. Box 14142, Kathmandu, Nepal.
On April 2011

Dear team JCDR, I would like to thank you for the very professional and polite service provided by everyone at JCDR. While i have been in the field of writing and editing for sometime, this has been my first attempt in publishing a scientific paper.Thank you for hand-holding me through the process.

Dr. Anuradha
On Jan 2020

Important Notice

Original article / research
Year : 2012 | Month : April | Volume : 6 | Issue : 2 | Page : 286 - 288

Treating Coexisting Sinusitis –Is It Beneficial In Treating Childhood Asthma?

Devaki Perumal Rajaram, Vaitheeswaran Natarajan

1. Assistant Professor, Dept.Of Physiology, Sree Balaji Medical College & Hospital, Chrompet,Chennai 600044, India. 2. Assistant professor,dept.of pediatrics, Kilpauk Medical College & Govt.Royapettah Hospital,Chennai 600014, India.

Correspondence Address :
Devaki P R,
Assistant Professor, Dept.Of Physiology,
F-1, A Block,Anandham Apartments,Solomon
Colony Road, Lakshmipuram, Chrompet,
Chennai 600044, India.
Phone: 9150051572


Background: Asthma frequently co-exists with other conditions like sinusitis, otitis media, allergic rhinitis and conjunctivitis. Sinusitis frequently triggers and affects the severity of asthma. Hence, it is necessary to diagnose and treat co morbid conditions like sinusitis.

Aim and objective: To determine the effect of the treatment of sinusitis on childhood asthma (with regard to its severity) and to measure the changes in the peak expiratory flow rate (PEFR) values as an objective evidence for the improvement of the disease.

Materials and methods: Two hundred and thirteen asthmatic children with symptoms which were suggestive of sinusitis, of the age group of 5-12 years were recruited for the study. They were graded for the severity of asthma on the basis of their clinical symptoms and their PEFR values. Sixty four children were diagnosed to have co-existing sinusitis, based on their clinical symptoms and on the findings of nasal scopy and radio imaging. These sixty four children were started on the treatment for sinusitis, along with asthma medication for three weeks. In the fourth week, again these children were evaluated for the severity of asthma, based on their clinical features and their PEFR values .

Results: After one month, the case load in grade II and grade I increased, while there was a decrease in the case load in grade III and grade IV, since the children with higher severity had shown improvement and as they had moved down to the lower grades of severity. As compared to the basal values, the mean PEFR, at 1 month, showed a statistically significant increase, thus providing an objective evidence for improvement.


Childhood asthma,Co -existing sinusitis, PEFR.

Childhood asthma has emerged as a chronic medical problem which is being treated by paediatricians all over the world. It poses a major problem in children, thus affecting their lifestyle and day to day activities, which include their schooling, sports and recreation. Despite the recent advances in the diagnosis and treatment of asthma, the disease per se and the treatment which is being offered for the disease in the form of bronchodilators and inhaled steroids, affects the psychological well being index of the sufferer as well as the care taker. Studies which were done on both children and adults have reported rhino sinusitis and asthma as the manifestations of a common inflammatory process (1). In a review which was done by Jani et al, they have described asthma and rhino sinusitis as two compartmental expressions of a common mucosal susceptibility to exogenous stimuli. In addition, it has also stated that there is evidence that these two compartmental processes can affect and amplify each other (2). Hence, it becomes necessary to diagnose and treat the coexisting sinusitis. Though studies have shown that rhino sinusitis worsens asthma, controversies exist as to whether treating sinusitis is effective in reducing the severity of childhood asthma. Hence, the aim of our study was to evaluate the effect of the treatment of coexisting sinusitis on the degree of severity of childhood asthma.

Material and Methods

Two hundred and thirteen asthmatic children who received an optimum therapy for asthma (in the form of salmeterol xinafoate Original Article Paediatrics Section 25 mcg with fluticasone propionate 50 mcg, two puffs twice a day, with a spacer and baby mask), who were in the age group of 5-12 years, of both the genders (males-97 and females -116), with the symptoms of sinusitis of more than 10 days duration, either during the first episode or recurrent episodes, were included in the study. A written informed consent was obtained from the parents of the children. The peak expiratory flow rate was determined by using Wright’s peak flow meter. The grading of the asthma as mild intermittent (grade-I) , mild persistent (grade II ), moderate persistent (grade III) and severe persistent (grade IV) was done on the basis of the symptoms and the PEFR values (3) in the children. The children with coexisting sinusitis were identified on the basis of their symptoms and the objective findings of nasal scopy such as inflammation of the nasal mucosa , discharge from the sinus opening, blockage of the nasal passage, scarring, crusting and the presence of polyps (4). In those children with coexisting sinusitis, antihistamines, decongestants and antibiotics were started in addition to the asthma medication. This therapy was continued for three weeks. No adjustment in the dosage of the asthma medication was done during the course of the study. At the end of the fourth week, they were assessed for the severity of asthma, based on their symptoms and the PEFR values which were measured before they took the morning dose of the inhaler. The PEFR values which were obtained before and after treating the coexisting sinusitis were analyzed by using the paired t-test and the SPSS software, version 11. This study was approved by the institutional ethical committee.


The incidence and the sex distribution of sinusitis
Among the 213 children, sinusitis was present in 64 children (30%) Thirty nine were female (61%) and twenty five were male children (39%). Of the 64 children with sinusitis, 2 were in the age group of 5 - 6 years, 11 were in the age group of 6 - 7 years, 17 were in the age group of 7 - 8 years, 13 were in the age group of 8 - 9 years, 8 each were in the age groups of 9-10 and 10- 11 years and 5 were in the 11 - 12 years age group.

Of the 64 children with sinusitis and asthma, 11 had grade I asthma, 21 had grade II asthma , 25 had grade III severity and 7 had grade IV asthma. The follow up at one month after treating the children with sinusitis, showed that of the 64 children with sinusitis and asthma, 19 had grade I asthma, 27 had grade II asthma, 12had grade III asthma and that 6 had grade IV asthma. There was a decrease in the number of children with grade III asthma (Table/Fig 1),(Table/Fig 2),(Table/Fig 3).


The purpose of our study was to explore the impact of the sinusitis management on the grades of the severity of asthma and to provide objective evidence for the same by measuring the changes in the PEFR values. Out of two hundred and thirteen asthmatic children who were included in our study, sixty four had coexisting sinusitis, which was about 30%. This finding was in par with those of the studies which were done by Grupp Phalen et al (5) and Krajewski et al., (6), who observed an incidence of 26% and 37.3% respectively. However, in a study which was done by Businco et al, they reported an incidence of about 68.7% (7).

In our study, the incidence of sinusitis was maximum in grade II and grade III asthma and the maxillary sinus was the most commonly involved sinus. This was in contradiction to the findings of the study which was done by Crater et al, where the C.T. findings in acute asthma revealed a mucosal thickening in the ethmoidal , frontal and the sphenoidal sinuses, but the maxillary sinus was not involved (8). In our study, we observed a marked change in the children with the grade III severity. The number of subjects in grade III decreased from 25 to 12 after they were treated for three weeks. This observation was similar to that which was made by Huan J et al., (9)and Buscino et al (7) and they had reported a considerable decrease in the severity of asthma after the therapy for sinusitis.

In our study, we also observed a significant increase in the PEFR values after three weeks of treatment for sinusitis. This finding was in par with that of the study which was done by Tosca et al, where they had reported a significant reduction in the asthma symptoms and also a significant improvement in the lung functions after the treatment for sinusitis (10). However, in a study which was done by Tsao et al., they had reported a significant improvement in the clinical signs of asthma, but no improvement was observed in the FEV1 values (11) . The effect of the treatment of sinusitis on the reduction of the severity of asthma has been a matter of dispute. Some authors consider sinusitis as a triggering factor for asthma, while some of them support the idea of a comorbidity. The reduction in the severity of the grade of asthma and an increase in the PEFR values which we observed are objective evidences of the effect of treating co-existing sinusitis in childhood asthma.

Though the exact mechanism of how the treatment of the sinusitis will reduce the severity of asthma is not clear, in a study which was done by Marney et al, they postulated the possible theories of how sinusitis can worsen asthma. It is possible that the aspiration of an infected sinus secretion may enter the lungs duringsleep. The infected sinus may enhance the vagal stimulation, thus causing a direct bronchospasm. The infected sinus may produce cytokines and brochoconstrictive mediators, thus worsening the asthma (12). Treating the sinusitis which coexists with asthma may probably interfere with any one of this mechanisms and thus reduce the severity of the asthma.

Despite the controversies which exist about the role of the sinusitis treatment in the treatment of asthma , studies have made it very clear that sinusitis worsens the symptoms of asthma .Hence, with the observations which were made from our study, we would like to conclude that a prompt diagnosis and treatment of the sinusitis definitely play an important role in the long term management of the asthma, which in turn, can aid in the normalization of the pulmonary functions, improve the peak flow expiratory rate and in particular, reduce the long term use of bronchodilators and corticosteroids, which may decrease the side effects which are caused by these drugs.


Pawankar, Rubya, Zernotti, Mario Eb. Rhinosinusitis in children and asthma severity. Current Opinion in Allergy and Clinical Immunology April 2009 ; 9 (2): 151-53.
Jani AL, Hamilos DL. Current thinking on the relationship between rhinosinusitis and asthma. J Asthma 2005; 42:1-7.
Guidelines for the Diagnosis and Management of Asthma–Update on Selected Topics (2002). NIH publication no: 02–5075.
Lund VJ, Kennedy DW. The Staging and Therapy Group. Quantification for staging sinusitis. Ann Otol Rhinol Laryngol Suppl. 1995;167:17-21.
Grupp - Phelan, et al. The health care utilization and costs in children with asthma and selected co-morbidities. Asthma 2001 Jun ; 38 (4) :363- 73.
Krajewski Z, et al. Prevalence of nasal sinusitis in children with bronchial asthma - Pneumonol Alergol Po. 1997 ; 65 Suppl 1:40 - 3.
Businco L, et al. Clinical and therapeutic aspects of sinusitis in children with bronchial asthma. Int J. Paediatr Otorhino Laryngol. 1981 Dec; 3 (4) : 287-94.
Crater SE, Peters EJ, Phillips CD, Platts-mills TA. Prospective analysis of CT of the sinuses in acute asthma. AJR Am J Roentgenol 1999; 173:127-31.
Huang JL, et al. Sinusitis and bronchial asthma in children. Zhoghua Min Guo Xiao Er Key Yi Xue Hui Za Zhi 1995. Jan – Feb; 36 (1):23.
Tosca MA, Cosentino C, Pallestrini E, et al. Improvement of the clinical and immunopathologic parameters in asthmatic children who were treated for concomitant chronic rhinosinusitis. Ann Allergy Asthma Immunol 2003; 91:71-78.
Tsao CH, Chen LC, Yeh KW, Huang JL. Concomitant chronic sinusitis treatment in children with mild asthma: the effect on the bronchial hyperresponsiveness. Chest 2003; 123:757-64.
Marney SR. Jr. Pathophysiology of the reactive airway disease and sinusitis. Department of Medicine, Vanderbilt University, Medicalcenter, Nashville, Tennessee USA. Ann Otol Rhinol Laryngol. 1996 Feb; 105 (2) 98-100.

DOI and Others

DOI: JCDR/2012/4154:2010


Date Of Submission: Feb 17, 2012
Date Of Peer Review: Mar 03, 2012
Date Of Acceptance: Mar 28, 2012
Date Of Publishing: Apr 15, 2012

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