Sclerosing Extramedullary Haematopoietic Tumour Presenting as Bilateral Gluteal Abscess in a Patient with Chronic Myelogenous LeukaemiaCorrespondence Address :
KS Sunil Kumar,
Consultant, Department of Histopathology, Apollo Hospitals, Greams Road, Chennai-600006, Tamil Nadu, India.
Sclerosing Extramedullary Haematopoietic Tumours (SEMHT) are found to be associated with Chronic Myeloproliferative Neoplasms most commonly reported in the skin, lacrimal system, orbit, omentum and liver. A 26-year-old male with a known history of Chronic Myelogenous Leukaemia (CML) sought medical attention for non-healing ulcerated lesions on both gluteal regions. Histopathological examination revealed patchy skin ulceration with dermal abscess formation, dense-periadnexal and perivascular extramedullary haematopoietic elements comprising of erythroid progenitors, granulocytes with all stages of maturation and atypical megakaryocytes extending into subcutaneous fat. Immunohistochemistry confirmed the lineage of erythroid progenitors by Glycophorin, granulocyte lineage by Myeloperoxidase and megakaryocytes by CD61 staining. CD34, CD30 and CD15 immunoreactivity were negative. Keeping this differential diagnosis in mind is essential while reporting a sclerotic lesion with extramedullary haematopoietic elements in a clinical setting of Chronic Myeloproliferative Neoplasms to prevent inaccurate diagnosis and unnecessary surgeries.
Atypical megakaryocytes, Chronic myeloproliferative neoplasms, Lacrimal system
KS Sunil Kumar, N Geetha, L Swetha, Prabu. SCLEROSING EXTRAMEDULLARY HAEMATOPOIETIC TUMOUR PRESENTING AS BILATERAL GLUTEAL ABSCESS IN A PATIENT WITH CHRONIC MYELOGENOUS LEUKAEMIA. Journal of Clinical and Diagnostic Research [serial online] 2018 December [cited: 2018 Dec 18 ]; 12:ED16-ED18. Available from
Date of Submission: Jul 29, 2018
Date of Peer Review: Aug 09, 2018
Date of Acceptance: Oct 10, 2018
Date of Publishing: Dec 01, 2018
FINANCIAL OR OTHER COMPETING INTERESTS: None.
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