A Clinical, Randomised, Double-Blind Study on the Use of Nano-Hydroxyapatite and Arginine During at-Home Tooth BleachingCorrespondence Address :
Dr. Cecy Martins Silva,
Avenue Augusto Corrêa nº 1, Guamá, Belém-66075-110, PA, Brazil.
Introduction: Home bleaching is a popular cosmetic technique that delivers quick results, reduces chair time, and has a lower risk of side effects compared to office bleaching.
Aim: To evaluate the effect of nano-hydroxyapatite (n-HAP) and arginine on Bleach-Sensitive Teeth (BST) and colour change after at-home bleaching treatment across three months of follow-up.
Materials and Methods: Sixty subjects were randomly allocated into one of three groups (n=20): 1) CONTROL, treated with 22% carbamide peroxide (CP)+toothpaste without a desensitising agent; 2) NANO, treated with CP +n-HAP; and 3) ARGININE, treated with CP + arginine. An air jet was used to evaluate BST associated with a modified Visual Analog Scale (VAS). A spectrophotometer was used to measure the colour of the maxillary incisors.
Results: The Friedman vs Kruskal-Wallis tests showed that the BST reported in the experimental groups was lower when compared with the control group one day after the end of treatment (p=0.05). However, no significant difference was observed at 30, 60 or 90 days of evaluation (p>0.05). ANOVA showed no significant difference between groups when comparing mean ?E (p>0.05).
Conclusion: The subjects treated with n-HAP and arginine presented lower sensitivity when compared to the control group one day after the end of treatment. In addition, there was no impairment of the efficacy of the at-home bleaching treatment over the 90-day evaluation period.
Clinical trial, Colour, Desensitising agents, Tooth sensitivity
Ranna Castro da Silva, Cristiane de Melo Alencar, Beatriz Helena Rodrigues Silva, Brennda Lucy Freitas de Paula, Antonia Patricia Oliveira Barros, Ana Daniela Silva da Silveira, et al.. A CLINICAL, RANDOMISED, DOUBLE-BLIND STUDY ON THE USE OF NANO-HYDROXYAPATITE AND ARGININE DURING AT-HOME TOOTH BLEACHING. Journal of Clinical and Diagnostic Research [serial online] 2018 December [cited: 2018 Dec 18 ]; 12:ZC01-ZC05. Available from
Date of Submission: Jun 03, 2018
Date of Peer Review: Jul 13, 2018
Date of Acceptance: Aug 16, 2018
Date of Publishing: Dec 01, 2018
Financial OR OTHER COMPETING INTERESTS: None.
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