Prolidase Activity and Oxidative Stress in Patients with GliomaCorrespondence Address :
Dr. Ragini Srivastava,
Associate Professor, Department of Biochemistry, Institute of Medical Sciences, Banaras Hindu University,
Varanasi-221005, Uttar Pradesh, India.
Introduction: Glioma is a glial cell tumour. Altered inflammatory responses and oxidative stress can be associated with induction of angiogenesis and uncontrolled growth of cells. Prolidase is a metalloenzyme also associated with angiogenesis and cancer. However, studies on prolidase and oxidative stress in glioma patients are limited.
Aim: To observe the prolidase activity and oxidative stress markers, such as Total Oxidant Status (TOS), Total Antioxidant Status (TAS) And Oxidative Stress Index (OSI), in patients with glioma.
Materials and Methods: Total 46 patients with glioma, 20 cadaver and 46 healthy volunteers of age and gender matched were selected as Cases, Control-1 and Control-2, respectively. Blood and brain tissues of respective area of cases and Control-1 were collected, while only blood was collected from Control-2. After brain tissue homogenisation and sera separation, prolidase activity and oxidative stress parameters were assessed spectrophotometrically.
Results: Prolidase activity and oxidative stress was found to be significantly elevated in the glioma tissues as well as sera of the patients with glioma as compared to healthy and cadaver controls (all p<0.01). Total oxidant status and oxidative stress index were also significantly elevated in glioma tissues and sera of patients with glioma, while total antioxidant status was significantly decreased (all p<0.01).
Conclusion: The present study showed that prolidase activity and oxidative stress markers such as TOS and OSI were significantly elevated in the patients with glioma, while level of TAS was decreased. Thus, it seems that elevated prolidase activity and oxidative stress markers might be associated with the pathogenesis of glioma.
Glial cell tumour, Total antioxidant status, Total oxidant status
Akhilesh Kumar Verma, Kulwant Singh, Surendra Kumar Pandey, Ragini Srivastav. PROLIDASE ACTIVITY AND OXIDATIVE STRESS IN PATIENTS WITH GLIOMA. Journal of Clinical and Diagnostic Research [serial online] 2018 October [cited: 2018 Sep 26 ]; 12:BC07-BC10. Available from
Date of Submission: May 29, 2018
Date of Peer Review: Jul 12, 2018
Date of Acceptance: Jul 27, 2018
Date of Publishing: Oct 01, 2018
Financial OR OTHER COMPETING INTERESTS: None.
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