Effect of Age and Hypertension on Cognition: A Cross-sectional StudyCorrespondence Address :
Dr. Murali Alagesan,
Department of Medicine, PSG Institute of Medical Sciences and Research, Peelamedu, Coimbatore, Tamil Nadu, India.
E-mail: muralimd email@example.com
Introduction: Cognitive impairment has evolved as major health and social issue. As age advances cognitive tasks involving processing speed, working memory and executive function get affected. Cognitive impairment is also influenced by modifiable risk factors such as hypertension, diabetes mellitus and hypercholesterolemia.
Aim: To find out the effect of age and hypertension on cognition.
Materials and Methods: The total study participants were divided into three groups based on their age as group I (18-29) group II (30-59) and group III (above 60) with 20 participants (n= 20) in each group. Their cognition was assessed using Mini Mental State Examination, Picture word Learning test, Stroop colour word test, Letter digit coding test, Verbal fluency and Logic memory tests. Disease history and known co morbidities (hypertension) were noted. Post-hoc test (Bonferroni) was employed to assess age-wise comparison of cognition and Pearson’s chi-square test was used to compare cognition between hypertensive and normotensives.
Results: Group II had impaired cognition when compared with group I (p-value- 0.000). Group III had impaired cognition when compared with group I (p-value- 0.000) and group II (p-value 0.001). The hypertensives in group II and III had statistically significant impairment in cognition when compared with normotensives (p-value -0.001) in the same group.
Conclusion: Cognitive functions are impaired as a result of increase in age. Furthermore, there is also a significant decrease in cognitive functions amongst those suffering from hypertension. Hence, we conclude there is decrease in cognitive function as age advances and the co-existence of hypertension hastens this decline.
Cognitive impairment, Mini mental state examination, Old age
Deepalakshmi Kaliyaperumal, Vijayabas Karan Shanmuga Varadharajan, Varsha Viswanathan, Murali Alagesan. EFFECT OF AGE AND HYPERTENSION ON COGNITION: A CROSS-SECTIONAL STUDY. Journal of Clinical and Diagnostic Research [serial online] 2018 September [cited: 2018 Sep 18 ]; 12:OC05-OC08. Available from
Date of Submission: Sep 15, 2017
Date of Peer Review: Nov 27, 2017
Date of Acceptance: May 26, 2018
Date of Publishing: Sep 01, 2018
FINANCIAL OR OTHER COMPETING INTERESTS: NONE
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