The Effect of a 16-week Home-based Aerobic Exercise Program on Serum High-sensitivity C-Reactive Protein (Hs-CRP) and Insulin Resistance in Polycystic Ovary SyndromeCorrespondence Address :
Nahid Mohammadi Javid,
PhD, Department of Sport Physiology, Kermanshah Branch, Islamic Azad University (IAU), Kermanshah, Iran.
Introduction: Polycystic Ovarian Syndrome (PCOS) is one of the most common hormonal disorders that affect 10 to 15% of women of reproductive age. Women with PCOS are at risk for complications such as pregnancy poor outcomes, insulin resistance, Type 2 Diabetes Mellitus (T2DM), metabolic syndrome, cardiovascular diseases and some malignant conditions where increase in serum C-reactive protein (CRP) level is known to be a marker.
Aim: To investigate the effect of a 16-week home-based aerobic exercise program on high-sensitivity CRP (hs-CRP) and insulin resistance index in females with PCOS.
Materials and Methods: In this quasi-experimental study, 24 female patients with PCOS were included and were divided into experimental (a home-based aerobic exercise program for 16 weeks) group (12 subjects) and control group (no intervention, 12 subjects). Serum hs-CRP and insulin resistance index (HOMA-IR) were measured and compared between the two groups. The paired t-test was used to compare the variables at baseline and after 16-weeks.
Results: Mean (±SD) hs-CRP level in experimental group at baseline was 6.31 (±2.64) mg/L which decreased to 3.91 (±1.59) mg/L (p=0.004). Mean (±SD) HOMA-IR in the experimental group at baseline was 3.24 (±1.3) which decreased to 1.87 (±0.47) after 16-weeks. However, no significant change in hs-CRP or HOMA-IR was seen in control group.
Conclusion: The home-based aerobic exercise program had a beneficial effect on improving insulin sensitivity (decrease in HOMA-IR) and reduction in hs-CRP in women with PCOS. This exercise could be recommended as a safe treatment for these patients.
Exercise, Inflammation, Polycystic ovarian syndrome
Nahid Mohammadi Javid, Naser Behpour, Vahid Tadibi. THE EFFECT OF A 16-WEEK HOME-BASED AEROBIC EXERCISE PROGRAM ON SERUM HIGH-SENSITIVITY C-REACTIVE PROTEIN (HS-CRP) AND INSULIN RESISTANCE IN POLYCYSTIC OVARY SYNDROME. Journal of Clinical and Diagnostic Research [serial online] 2019 August [cited: 2019 Aug 20 ]; 13:CC01-CC04. Available from
Date of Submission: Feb 05, 2019
Date of Peer Review: Mar 18, 2019
Date of Acceptance: Jun 27, 2019
Date of Publishing: Aug 01, 2019
FINANCIAL OR OTHER COMPETING INTERESTS: None.
- Emerging Sources Citation Index (Web of Science, thomsonreuters)
- Index Copernicus ICV 2017: 134.54
- Academic Search Complete Database
- Directory of Open Access Journals (DOAJ)
- Google Scholar
- HINARI Access to Research in Health Programme
- Indian Science Abstracts (ISA)
- Journal seek Database
- Popline (reproductive health literature)