Effect of Vitamin D Replacement on Serum TSH in Women with Anti-TPO Positive Sub-clinical HypothyroidismCorrespondence Address :
Dr. Farzad Najafipour,
Department of Endocrinology, Emam Reza Hospital, Endocrine Research Center,
Tabriz University of Medical Sciences, Tabriz, Iran.
Introduction: The coexistence of Sub-Clinical Hypothyroidism (SCH) and vitamin D deficiency is a common problem and may lead to various clinical disorders. Several genetic studies have shown an association between gene polymorphism of Vitamin D receptor and of 1a hydroxylase with autoimmune thyroid diseases.
Aim: To evaluate the effects of vitamin D3 replacement on Thyroid-Stimulating Hormone (TSH) and anti-TPO levels in women with SCH.
Materials and Methods: This clinical trial was performed on 58 Sub-Clinical Hypothyroidism vitamin D deficient women. Patients were treated with 50,000 unit/week vitamin D3 capsule for eight weeks and TSH, Free thyroxine (FT4) and anti-TPO levels were measured before and after drug administration, using an electrochemiluminescence system.
Results: The mean age of the population was 38.02±12.68 years. Vitamin D3 replacement caused serum 25(OH) D3 level correction in SCH patients (p<0.001). Additionally, a significant decrease in anti-TPO and TSH levels were also observed in anti-TPO positive patients (n=29) (p=0.002 and p=0.02, respectively). No significant differences in anti-TPO and TSH levels were seen in anti-TPO negative group (p=0.507 and p=0.447, respectively).
Conclusion: The study showed that vitamin D3 replacement may be considered as an effective therapy to reduce TSH and anti-TPO levels in vitamin D deficient SCH patients.
Anti-thyroid peroxidase, Autoimmune thyroiditis, Free thyroxine, Sub-clinical hypothyroidism, Thyroid stimulating hormone, Vitamin D deficiency
Kiarash Aminian, Amir Bahrami, Mostafa Najafipour, Farzad Najafipour. EFFECT OF VITAMIN D REPLACEMENT ON SERUM TSH IN WOMEN WITH ANTI-TPO POSITIVE SUB-CLINICAL HYPOTHYROIDISM. Journal of Clinical and Diagnostic Research [serial online] 2019 January [cited: 2019 Jan 22 ]; 13:OC01-OC03. Available from
Date of Submission: Aug 06, 2018
Date of Peer Review: Sep 29, 2018
Date of Acceptance: Oct 01, 2018
Date of Publishing: Jan 01, 2019
FINANCIAL OR OTHER COMPETING INTERESTS: None.
- Emerging Sources Citation Index (Web of Science, thomsonreuters)
- Index Copernicus ICV 2016: 132.37
- Academic Search Complete Database
- Directory of Open Access Journals (DOAJ)
- Embase & EMbiology
- Google Scholar
- HINARI Access to Research in Health Programme
- Indian Science Abstracts (ISA)
- Journal seek Database
- Popline (reproductive health literature)