Syringocystadenocarcinoma Papilliferum- An Uncommon Malignant Adnexal Neoplasm at an Unusual LocationCorrespondence Address :
Dr. BN Kumarguru,
‘Sri’ nivasa. No:204. 9th Cross, BEML Layout, 1st Stage, Basaveshwaranagara, Bengaluru-560079, Karnataka, India.
Syringocystadenocarcinoma Papilliferum (SCACP) is a rare adnexal malignant neoplasm. Most of the cases present with a long standing mass with a sudden progression in size. A 60-year-old female presented with history of swelling over the antero-lateral aspect of left thigh since three years. The lesion was associated with history of pain and ulceration. Grossly, the external surface showed three ulcerated areas. The largest ulcer measured 4×5.5 cm. On cut section, the tumour showed variegated appearance consisting of grey-white to pink areas, multiple cysts, focal necrosis and hemorrhagic areas. Microscopically, tumour cells were arranged in papillary configuration, solid sheets, tubular and acinar pattern. Individual tumour cells showed pleomorphic vesicular nucleus and mitotic figures. The intervening connective tissue showed dense chronic inflammatory cell infiltrate composed of lymphocytes, plasma cells and eosinophils. Also seen were areas of necrosis and Gamna-Gandy body. Based on histological features, a diagnosis of malignant appendageal tumour of the skin with apocrine differentiation, favouring SCACP was offered. By Immunohistochemistry (IHC), tumour cells showed focal positivity for CEA and negative for GCDFP-15. IHC may be helpful, but a pathologist has to primarily depend on the histopathological characteristics of the lesion for diagnosing the condition.
Cysts, Necrosis, Plasma cells, Ulcer
Saranya Shankar, BN Kumarguru, CA Arathi, AS Ramaswamy, R Prashanth. SYRINGOCYSTADENOCARCINOMA PAPILLIFERUM- AN UNCOMMON MALIGNANT ADNEXAL NEOPLASM AT AN UNUSUAL LOCATION. Journal of Clinical and Diagnostic Research [serial online] 2019 July [cited: 2019 Jul 23 ]; 13:ED01-ED04. Available from
Date of Submission: Feb 21, 2019
Date of Peer Review: Mar 30, 2019
Date of Acceptance: Apr 29, 2019
Date of Publishing: Jul 01, 2019
FINANCIAL OR OTHER COMPETING INTERESTS: None.
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