An Interesting Case of Acute Encephalitic Syndrome with Pancytopenia and SplenomegalyCorrespondence Address :
Dr. Satyendra Kumar Sonkar,
King George’s Medical University, Lucknow-226003, Uttar Pradesh, India.
Human Parvovirus infection is a rare condition causing encephalitis as well as pancytopenia. Similarly patient of Wilson disease presenting as hepatic encephalopathy as an initial manifestation is also a rare phenomenon. A previously healthy 20-year-old female patient presented as acute encephalitis syndrome with hepatitis and pancytopenia. Bone marrow examination showed the presence of inclusion bodies and PCR (Polymerase Chain Reaction) showed the presence of DNA of human parvo virus B19. Patient was suspected as a case of Wilson’s disease due to the persistence of splenomegaly and radiological findings and was confirmed by increased 24 hours urinary copper and low level of serum ceruloplasmin. Patient was treated symptomatically and gained consciousness and pancytopenia improved over course of time.
Human parvovirus B 19, Serum ceruloplasmin, Wilson’s disease
Satyendra Kumar Sonkar, Satish Kumar, Neeraj Kumar Singh. AN INTERESTING CASE OF ACUTE ENCEPHALITIC SYNDROME WITH PANCYTOPENIA AND SPLENOMEGALY. Journal of Clinical and Diagnostic Research [serial online] 2019 March [cited: 2019 Apr 25 ]; 13:OD08-OD10. Available from
Date of Submission: Dec 03, 2018
Date of Peer Review: Dec 14, 2018
Date of Acceptance: Jan 11, 2019
Date of Publishing: Mar 01, 2019
FINANCIAL OR OTHER COMPETING INTERESTS: None.
- Emerging Sources Citation Index (Web of Science, thomsonreuters)
- Index Copernicus ICV 2017: 134.54
- Academic Search Complete Database
- Directory of Open Access Journals (DOAJ)
- Google Scholar
- HINARI Access to Research in Health Programme
- Indian Science Abstracts (ISA)
- Journal seek Database
- Popline (reproductive health literature)