Prediction of Chronic Obstructive Pulmonary Disease using Computed Tomography Measurements of Pulmonary Artery and Aortic DiameterCorrespondence Address :
Assistant Professor, Department of Medical Imaging Technology, School of Allied Health Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, India.
Introduction: Chronic Obstructive Pulmonary Disease (COPD) is a group of progressive lung disease which commonly includes emphysema and chronic bronchitis. Among the non-communicable disease, COPD is estimated to be second largest cause of death in India. Computed Tomography (CT) of Chest and measurements of arteries could be a simple and effective modality for diagnostic evaluation of COPD.
Aim: To determine whether CT measurements such as Pulmonary artery and aortic artery diameters are useful in predicting COPD.
Materials and Methods: A total of 291 patients were included in this retrospective study who had undergone CT thorax from April 2016 to April 2018. 194 patients (120 males, 74 females) with COPD were taken as cases and 97 patients (58 males, 39 females) without any history of COPD were taken as controls.Diameters such as Main Pulmonary Artery (MPA), Right Pulmonary Artery (RPA), Left Pulmonary Artery (LPA), Ascending Aorta (Aao) And Descending Aorta (Dao) were measured on an axial CT thorax image. Ratios of MPA/AAo and MPA/DAo were also calculated. Mann-Whitney U-test was used to compare CT measurements between two groups. Receiver Operating Characteristic (ROC) curve was used to find sensitivity and specificity of CT measurements in predicting COPD.
Results: The sensitivity and specificity for MPA, RPA, LPA, AAo, DAo, MPA/AAo and MPA/DAo was 77.3% and 83%, 74.8% and 79.5%, 71.8 and 78.8, 56.7% and 42.6%, 30.1 and 60.3, 17.3% and 33.8%, 18.9% and 33.8% respectively. There was significant difference in diameters such as MPA, RPA, LPA, AAo and Dao among two groups (p-value <0.001) where as, no significant difference was found in MPA/AAo and MPA/DAo ratios between two groups (p-value >0.001).
Conclusion: In present study, authors found a significant increase in MPA, RPA and LPA diameters in COPD patients compared to controls. Henceforth, the present study concludes that MPA, RPA and LPA diameters could be useful as reliable indicators in predicting COPD.
Aortic diameter, Chronic obstructive pulmonary disease, Computed tomography, Left pulmonary artery diameter, Main pulmonary artery diameter, Right pulmonary artery diameter
Priyanka, Saikiran Pendem, Abhijith Ajayamandiram, Adarsh Veer Sisoudiya. PREDICTION OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE USING COMPUTED TOMOGRAPHY MEASUREMENTS OF PULMONARY ARTERY AND AORTIC DIAMETER. Journal of Clinical and Diagnostic Research [serial online] 2019 March [cited: 2019 Feb 18 ]; 13:TC04-TC06. Available from
Date of Submission: Oct 30, 2018
Date of Peer Review: Dec 18, 2018
Date of Acceptance: Jan 07, 2019
Date of Publishing: Mar 01, 2019
FINANCIAL OR OTHER COMPETING INTERESTS: None.
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