
Immune Thrombocytopenia causing Abnormal Uterine Bleeding in an Adolescent Girl having Co-Existent Type-1 Neurofibromatosis- Is it an Association or Coincidence?
Correspondence Address :Charu Sharma,
All India Institute of Medical Sciences, Jodhpur, Rajasthan, India.
E-mail: sharma.charu651@gmail.com
Immune Thrombocytopenia (ITP) is an autoimmune disorder characterised by a low circulating platelet count. ITP is caused by destruction of antibody-sensitised platelets in the reticuloendothelial system. Majority of the patients with ITP remain asymptomatic or develop only purpura, petechiae or epistaxis (83%) but few, very rarely, may present with abnormal uterine bleeding. On the other hand, Neurofibromatosis is an autosomal dominant disorder which can present with either precocious puberty or delayed puberty. This case report highlights a case of a 14-year-old female who presented with heavy menstrual bleeding as a presenting symptom of ITP and was co-incidentally also diagnosed as Neurofibromatosis type 1 (NF-1) during work-up of ITP for multiple hyperpigmented macules (Cafè-au-lait spots) noticed on her neck, forearm and back and the presence of Lisch nodules in iris. She was managed with steroids, oral contraceptive pills, iron and multivitamin tablets.
Café-au-lait spots, Heavy menstrual bleeding, Lisch nodules, Platelet count, Steroids
DOI: 10.7860/JCDR/2020/45876.14180
Date of Submission: Jul 13, 2020
Date of Peer Review: Aug 27, 2020
Date of Acceptance: Sep 16, 2020
Date of Publishing: Nov 01, 2020
AUTHOR DECLARATION:
• Financial or Other Competing Interests: None
• Was informed consent obtained from the subjects involved in the study? Yes (from parents)
• For any images presented appropriate consent has been obtained from the subjects. Yes (from parents)
PLAGIARISM CHECKING METHODS:
• Plagiarism X-checker: Jul 14, 2020
• Manual Googling: Sep 15, 2020
• iThenticate Software: Oct 15, 2020 (4%)
ETYMOLOGY: Author Origin
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- Indian Science Abstracts (ISA)
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