A Unique Constitutional Robertsonian Translocation t(13;14) Associated with Severe Aplastic Anaemia
Correspondence Address :
Dr. Shailendra Prasad Verma,
1/167, Vikas Nagar, Lucknow, Uttar Pradesh, India.
E-mail: spverma1998@gmail.com
Aplastic anaemia is characterised by cytopenias and hypocellular bone marrow without any evidence of marrow fibrosis or marrow infiltration. There is no specific cytogenetic abnormality associated with aplastic anaemia. Most common abnormalities are trisomies of chromosome 6, 8 and loss of 7. A 17-year-old female, presented with generalised weakness, exertional breathlessness and menorrhagia for last six months. She also gave a history of 12 units Packed Red Blood Cells (PRBC) transfusion, at the rate of 2-3 units per month in the last five months. Routine haematology showed severe pancytopenia with reticulocytopenia. Bone marrow evaluation revealed hypoplastic marrow with 15% bone marrow cellularity suggesting aplastic anaemia. Karyotyping using Giemsa (GTG) banding of unstimulated culture showed a very unique constitutional Robertsonian Translocation (RT) karyotype 45+XX, der(13;14)(q10;q10). Patient responded partially to treatment with cyclosporine and anabolic steroids. The final diagnosis was severe aplastic anaemia associated with constitutional RT t(13;14) karyotype. Although cytogenetic abnormalities are neither common nor specific in aplastic anaemia, some of them can have diagnostic and therapeutic implications.
Bone marrow failure, Cyclosporine, Cytogenetic abnormalities, Karyotyping
10.7860/JCDR/2021/50176.15389
Date of Submission: May 01, 2021
Date of Peer Review: Jun 22, 2021
Date of Acceptance: Jul 16, 2021
Date of Publishing: Sep 01, 2021
AUTHOR DECLARATION:
• Financial or Other Competing Interests: None
• Was informed consent obtained from the subjects involved in the study? Yes
• For any images presented appropriate consent has been obtained from the subjects. Yes
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• Plagiarism X-checker: May 05, 2021
• Manual Googling: Jul 15, 2021
• iThenticate Software: Aug 10, 2021 (4%)
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