Association between Non Alcoholic Fatty Liver Disease and Severity of Coronary Artery Disease in Patients Aged 45 Years and Below with Acute Coronary Syndrome
Correspondence Address :
Dr. Raja Affendi Raja Ali,
Gastroenterology Unit, Faculty of Medicine, The National University of Malaysia,
Jalan Yaacob Latif, Bandar Tun Razak, Cheras, Kuala Lumpur-56000, Malaysia.
E-mail: draffendi@ppukm.ukm.edu.my
Introduction: Coronary Artery Disease (CAD) is an important extrahepatic cardiovascular complication of Non Alcoholic Fatty Liver Disease (NAFLD).
Aim: To determine the prevalence of NAFLD in young (≤45 years) Acute Coronary Syndrome (ACS) patients, and to assess the association between severity of NAFLD and severity of CAD.
Materials and Methods: This cross-sectional study was conducted from May 2017-April 2018, with a total of 85 patients. CAD severity was determined by coronary angiogram while its complexity by SYNTAX score. Fatty liver was diagnosed and graded by liver ultrasound examination.
Results: The prevalence of NAFLD was 100%. Thirty-three (38.9%) had ST-Elevation Myocardial Infarction (STEMI), 32 (37.6%) had Non STEMI (NSTEMI) and 20 (23.5%) had unstable angina. There was no significant correlation between NAFLD steatosis grades and ACS subtypes (p=0.721), severity of CAD (p=0.822) and SYNTAX score (p=0.982). No association between NAFLD fibrosis score and ACS subtypes (p=0.232), severity of CAD (p=0.445) or SYNTAX score (p=0.839) were observed.
Conclusion: The NAFLD was extremely prevalent in young ACS patients. However, no significant association between severity of NAFLD and severity of CAD was found.
Fibrosis score, Hepatic steatosis, Myocardial infarction, Prevalence, Young
10.7860/JCDR/2021/51150.15690
Date of Submission: Jul 01, 2021
Date of Peer Review: Aug 17, 2021
Date of Acceptance: Sep 22, 2021
Date of Publishing: Nov 01, 2021
AUTHOR DECLARATION:
• Financial or Other Competing Interests: None
• Was Ethics Committee Approval obtained for this study? Yes
• Was informed consent obtained from the subjects involved in the study? Yes
• For any images presented appropriate consent has been obtained from the subjects. NA
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• Plagiarism X-checker: Jul 02, 2021
• Manual Googling: Sep 20, 2021
• iThenticate Software: Sep 13, 2021 (13%)
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