Primitive Neuroectodermal Tumour of Uterine Cervix: A Rare Case Report and Review of Literature
Correspondence Address :
Dr. Saumya Shukla,
Dr. Ram Manohar Lohia Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.
E-mail: saumyavarun@gmail.com
Primitive Neuroectodermal Tumour (PNET) of the uterine cervix is a rare entity. Till date, less than 25 cases have been reported from 1987-2021. Histopathologically, tumour is composed of small round blue cells, developing from neuroectodermal cells. Awareness of this rare entity is important from clinical, radiological and pathological aspect for prompt management. A 67-year-old female presented with abnormal vaginal bleeding and lower abdominal pain since two months. Computed Tomography (CT) and Magnetic Resonance Imaging (MRI) of the abdomen revealed the presence of a large mass measuring 71×63×47 mm in size along with, enlarged inguinal lymph nodes. Pathological examination of the tumour revealed a small round cell neoplasm, immunohistochemically positive for CD99 (Cluster of Differentiation) and Friend Leukaemia Intergration-1 (FLI-1). Diagnosis of PNET uterine cervix was rendered. Molecular testing for (Ewing Sarcoma breakpoint region 1) EWS/FLI-1 fusion transcripts could not be performed. Despite administration of the first cycle of adjuvant chemotherapy, the patient died from disease due to pulmonary metastasis. Due to unusual site and small round cell morphology, this entity may present as a diagnostic challenge to the pathologist.
Inguinal lymph nodes, Metastasis, Neuroectodermal cells, Small round blue cell tumour, Uterine neoplasm
DOI: 10.7860/JCDR/2021/50706.15767
Date of Submission: Jun 06, 2021
Date of Peer Review: Aug 15, 2021
Date of Acceptance: Oct 27, 2021
Date of Publishing: Dec 01, 2021
AUTHOR DECLARATION:
• Financial or Other Competing Interests: None
• Was informed consent obtained from the subjects involved in the study? Yes
• For any images presented appropriate consent has been obtained from the subjects. Yes
PLAGIARISM CHECKING METHODS:
• Plagiarism X-checker: Jun 07, 2021
• Manual Googling: Oct 21, 2021
• iThenticate Software: Nov 19, 2021 (4%)
ETYMOLOGY: Author Origin
- Emerging Sources Citation Index (Web of Science, thomsonreuters)
- Index Copernicus ICV 2017: 134.54
- Academic Search Complete Database
- Directory of Open Access Journals (DOAJ)
- Embase
- EBSCOhost
- Google Scholar
- HINARI Access to Research in Health Programme
- Indian Science Abstracts (ISA)
- Journal seek Database
- Popline (reproductive health literature)
- www.omnimedicalsearch.com