Journal of Clinical and Diagnostic Research, ISSN - 0973 - 709X

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On Sep 2018




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"Journal of Clinical and Diagnostic Research is at present a well-known Indian originated scientific journal which started with a humble beginning. I have been associated with this journal since many years. I appreciate the Editor, Dr. Hemant Jain, for his constant effort in bringing up this journal to the present status right from the scratch. The journal is multidisciplinary. It encourages in publishing the scientific articles from postgraduates and also the beginners who start their career. At the same time the journal also caters for the high quality articles from specialty and super-specialty researchers. Hence it provides a platform for the scientist and researchers to publish. The other aspect of it is, the readers get the information regarding the most recent developments in science which can be used for teaching, research, treating patients and to some extent take preventive measures against certain diseases. The journal is contributing immensely to the society at national and international level."



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Lucknow
On Sep 2018




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On Aug 2018




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Dr. Arundhathi. S
MBBS, MD (Pathology),
Sanjay Gandhi institute of trauma and orthopedics,
Bengaluru.
On Aug 2018




Dr. Mamta Gupta,
"It gives me great pleasure to be associated with JCDR, since last 2-3 years. Since then I have authored, co-authored and reviewed about 25 articles in JCDR. I thank JCDR for giving me an opportunity to improve my own skills as an author and a reviewer.
It 's a multispecialty journal, publishing high quality articles. It gives a platform to the authors to publish their research work which can be available for everyone across the globe to read. The best thing about JCDR is that the full articles of all medical specialties are available as pdf/html for reading free of cost or without institutional subscription, which is not there for other journals. For those who have problem in writing manuscript or do statistical work, JCDR comes for their rescue.
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Reviewing articles is no less a pain staking process and requires in depth perception, knowledge about the topic for review. It requires time and concentration, yet I enjoy doing it. The JCDR website especially for the reviewers is quite user friendly. My suggestions for improving the journal is, more strict review process, so that only high quality articles are published. I find a a good number of articles in Obst. Gynae, hence, a new journal for this specialty titled JCDR-OG can be started. May be a bimonthly or quarterly publication to begin with. Only selected articles should find a place in it.
An yearly reward for the best article authored can also incentivize the authors. Though the process of finding the best article will be not be very easy. I do not know how reviewing process can be improved. If an article is being reviewed by two reviewers, then opinion of one can be communicated to the other or the final opinion of the editor can be communicated to the reviewer if requested for. This will help one’s reviewing skills.
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Dr. Mamta Gupta
Consultant
(Ex HOD Obs &Gynae, Hindu Rao Hospital and associated NDMC Medical College, Delhi)
Aug 2018




Dr. Rajendra Kumar Ghritlaharey

"I wish to thank Dr. Hemant Jain, Editor-in-Chief Journal of Clinical and Diagnostic Research (JCDR), for asking me to write up few words.
Writing is the representation of language in a textual medium i e; into the words and sentences on paper. Quality medical manuscript writing in particular, demands not only a high-quality research, but also requires accurate and concise communication of findings and conclusions, with adherence to particular journal guidelines. In medical field whether working in teaching, private, or in corporate institution, everyone wants to excel in his / her own field and get recognised by making manuscripts publication.


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Salient features of the JCDR: It is a biomedical, multidisciplinary (including all medical and dental specialities), e-journal, with wide scope and extensive author support. At the same time, a free text of manuscript is available in HTML and PDF format. There is fast growing authorship and readership with JCDR as this can be judged by the number of articles published in it i e; in Feb 2007 of its first issue, it contained 5 articles only, and now in its recent volume published in April 2011, it contained 67 manuscripts. This e-journal is fulfilling the commitments and objectives sincerely, (as stated by Editor-in-chief in his preface to first edition) i e; to encourage physicians through the internet, especially from the developing countries who witness a spectrum of disease and acquire a wealth of knowledge to publish their experiences to benefit the medical community in patients care. I also feel that many of us have work of substance, newer ideas, adequate clinical materials but poor in medical writing and hesitation to submit the work and need help. JCDR provides authors help in this regards.
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Indexation and online availability: Indexation transforms the journal in some sense from its local ownership to the worldwide professional community and to the public.JCDR is indexed with Embase & EMbiology, Google Scholar, Index Copernicus, Chemical Abstracts Service, Journal seek Database, Indian Science Abstracts, to name few of them. Manuscriptspublished in JCDR are available on major search engines ie; google, yahoo, msn.
In the era of fast growing newer technologies, and in computer and internet friendly environment the manuscripts preparation, submission, review, revision, etc and all can be done and checked with a click from all corer of the world, at any time. Of course there is always a scope for improvement in every field and none is perfect. To progress, one needs to identify the areas of one's weakness and to strengthen them.
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Every one of us: authors, reviewers, editors, and publisher are responsible for enhancing the stature of the journal. I wish for a great success for JCDR."



Thanking you
With sincere regards
Dr. Rajendra Kumar Ghritlaharey, M.S., M. Ch., FAIS
Associate Professor,
Department of Paediatric Surgery, Gandhi Medical College & Associated
Kamla Nehru & Hamidia Hospitals Bhopal, Madhya Pradesh 462 001 (India)
E-mail: drrajendrak1@rediffmail.com
On May 11,2011




Dr. Shankar P.R.

"On looking back through my Gmail archives after being requested by the journal to write a short editorial about my experiences of publishing with the Journal of Clinical and Diagnostic Research (JCDR), I came across an e-mail from Dr. Hemant Jain, Editor, in March 2007, which introduced the new electronic journal. The main features of the journal which were outlined in the e-mail were extensive author support, cash rewards, the peer review process, and other salient features of the journal.
Over a span of over four years, we (I and my colleagues) have published around 25 articles in the journal. In this editorial, I plan to briefly discuss my experiences of publishing with JCDR and the strengths of the journal and to finally address the areas for improvement.
My experiences of publishing with JCDR: Overall, my experiences of publishing withJCDR have been positive. The best point about the journal is that it responds to queries from the author. This may seem to be simple and not too much to ask for, but unfortunately, many journals in the subcontinent and from many developing countries do not respond or they respond with a long delay to the queries from the authors 1. The reasons could be many, including lack of optimal secretarial and other support. Another problem with many journals is the slowness of the review process. Editorial processing and peer review can take anywhere between a year to two years with some journals. Also, some journals do not keep the contributors informed about the progress of the review process. Due to the long review process, the articles can lose their relevance and topicality. A major benefit with JCDR is the timeliness and promptness of its response. In Dr Jain's e-mail which was sent to me in 2007, before the introduction of the Pre-publishing system, he had stated that he had received my submission and that he would get back to me within seven days and he did!
Most of the manuscripts are published within 3 to 4 months of their submission if they are found to be suitable after the review process. JCDR is published bimonthly and the accepted articles were usually published in the next issue. Recently, due to the increased volume of the submissions, the review process has become slower and it ?? Section can take from 4 to 6 months for the articles to be reviewed. The journal has an extensive author support system and it has recently introduced a paid expedited review process. The journal also mentions the average time for processing the manuscript under different submission systems - regular submission and expedited review.
Strengths of the journal: The journal has an online first facility in which the accepted manuscripts may be published on the website before being included in a regular issue of the journal. This cuts down the time between their acceptance and the publication. The journal is indexed in many databases, though not in PubMed. The editorial board should now take steps to index the journal in PubMed. The journal has a system of notifying readers through e-mail when a new issue is released. Also, the articles are available in both the HTML and the PDF formats. I especially like the new and colorful page format of the journal. Also, the access statistics of the articles are available. The prepublication and the manuscript tracking system are also helpful for the authors.
Areas for improvement: In certain cases, I felt that the peer review process of the manuscripts was not up to international standards and that it should be strengthened. Also, the number of manuscripts in an issue is high and it may be difficult for readers to go through all of them. The journal can consider tightening of the peer review process and increasing the quality standards for the acceptance of the manuscripts. I faced occasional problems with the online manuscript submission (Pre-publishing) system, which have to be addressed.
Overall, the publishing process with JCDR has been smooth, quick and relatively hassle free and I can recommend other authors to consider the journal as an outlet for their work."



Dr. P. Ravi Shankar
KIST Medical College, P.O. Box 14142, Kathmandu, Nepal.
E-mail: ravi.dr.shankar@gmail.com
On April 2011
Anuradha

Dear team JCDR, I would like to thank you for the very professional and polite service provided by everyone at JCDR. While i have been in the field of writing and editing for sometime, this has been my first attempt in publishing a scientific paper.Thank you for hand-holding me through the process.


Dr. Anuradha
E-mail: anuradha2nittur@gmail.com
On Jan 2020

Important Notice

Original article / research
Year : 2022 | Month : January | Volume : 16 | Issue : 1 | Page : DC10 - DC14 Full Version

Prevalence of Tuberculosis in the North Indian Subcontinent Kashmir Valley: A Cross-sectional Hospital-based Study


Published: January 1, 2022 | DOI: https://doi.org/10.7860/JCDR/2022/53062.15847
Aijaz Nabi Puttoo , Naveed Nazir Shah , Sandeep Tripathi , Ruqeya Nazir , Haamid Bashir , Rehana Kauser , Himanshu Tripathi , Inam Ul Haq

1. Research Scholar, Department of Medical Laboratory Technology, NIMS University, Shobha Nagar, Jaipur, Rajasthan, India. 2. Professor and Head, Department of Pulmonary Medicine, Chest Diseases Hospital, Government Medical College, Karan Nagar, Srinagar, Jammu and Kashmir, India. 3. Professor, Institute of Allied Health Sciences, NIMS University, Shobha Nagar, Jaipur, Rajasthan, India. 4. Assistant Professor, Center of Research for Development, Microbiology University of Kashmir, Hazratbal, Srinagar, Jammu and Kashmir, India. 5. Research Scholar, Department of Biochemistry, Government Medical College, Srinagar, Jammu and Kashmir, India. 6. State Tuberculosis Officer, Srinagar, Jammu and Kashmir, India. 7. Associate Professor and Principal, NIMS College of Paramedical Technology, NIMS University, Shobha Nagar, Jaipur, Rajasthan, India. 8. Assistant Professor, Department of Social and Preventive Medicine, Government Medical College, Karan Nagar, Srinagar, Jammu and Kashmir, India

Correspondence Address :
Dr. Aijaz Nabi Puttoo,
PhD Scholar, Department of Medical Laboratory Technology, NIMS University, NH-11C,
Jaipur-Delhi Highway, Shobha Nagar, Jaipur-303121, Rajasthan, India.
E-mail: aijaznabi27@gmail.com

Abstract

Introduction: Tuberculosis (TB) is an infectious bacterial disease caused by Mycobacterium tuberculosis, which most commonly affects the lungs. TB is one of the biggest public health challenges in the world especially in under-developing and developing countries.

Aim: To determine the prevalence of TB in the Kashmir valley.

Materials and Methods: The present cross-sectional study was conducted in the Department of Chest Medicine, Chest Diseases Hospital (CDH), Government Medical College, Srinagar and Intermediate Reference Laboratory (IRL), State TB Training and Demonstration Centre (STDC), CDH, Srinagar and in association with State TB Office (STO) Kashmir, India, from March 2019 to December 2020 in 10 districts. A total of 66,829 presumptive TB samples in 2019 inclusive of 450 samples of CDH and 63532 presumptive TB samples in 2020 inclusive of 400 samples of CDH were collected from Department of Chest Medicine, CDH, Government Medical College, Srinagar and Revised National TB Control Programme (RNTCP) Centres of Kashmir valley under State TB office Director Health Kashmir as per World Health Organisation (WHO) criteria. It included both the positive and negative cases of TB registered during the year 2019 and 2020.

Results: The total prevalence of TB disease during the year 2019 was found to be 49.03 per 100,000 population and 37.31 per 100,000 population in the year 2020 respectively. There was no correlation among the surveyed demographics in the positive TB cases in the Kashmir valley (p>0.05). Srinagar city reported highest cases whereas Budgam and Pulwama reported least cases in the year 2019 and 2020.

Conclusion: The respiratory precautionary measures like social distancing and use of face masks during the ongoing COVID-19 pandemic has reduced transmission and incidence of TB. Proper identification and treatment of infectious cases will prevent TB in the ethnic population. More studies are needed on large sample size.

Keywords

Acid fast bacillus, Chest diseases, Mycobacterium tuberculosis, Revised national tuberculosis control programme, Rural

The TB is a global health problem and it is highly infectious airborne bacterial disease caused by Mycobacterium tuberculosis, which most commonly affects the lungs in the human respiratory system. TB is a challenge globally, and it is a major cause of morbidity and mortality in millions of people each year. TB is ranked among the 10 causes of deaths worldwide and regarded as one of the leading causes of death from infectious diseases. India accounts for 1/4th of the global TB burden and it is reported that around 4.8 lac people died due to TB of estimated 28 lac infected cases in 2015 (1). As per latest TB report of WHO, TB remains a persistent developmental challenge worldwide and puts burden on exchequers (2). The proportion of TB infected patients is higher in India because of poor socio-economic and environmental conditions. According to National Family Health Survey (NFHS-4), the prevalence of TB is 316 per 100,000 persons in India (3). To achieve global target of “End TB 2035” is possible only due to decline of morbidity and mortality, new infections among population and elimination of economic and social burden of TB disease (4).

The first ever prevalence study on TB disease in Kashmir valley was conducted by Mayurnath S et al., and RNTCP was implemented in the valley in 2004 to stop further progression of TB disease in the Kashmir valley, which showed very good results and helped in decline of disease and removal of social stigma among patients regarding the disease and treatment (5). The Kashmir valley is a demographically mountainous region, where around four to five months witnesses winter season due to which people remain inside and use wood, coal, gas for heating and cooking purposes. Many studies reported indoor air pollution as a significant risk factor for the occurrence of TB disease (6),(7). The present literature suggested a number of factors associated with TB infection, including demographic, socio-economic and environmental factors, such as age, sex, level of education, marital status, place of residence, wealth, overcrowding, poor housing and household environment factors (8),(9),(10),(11).

To get a more precise understanding of the current TB burden in the Kashmir valley, there was a need to conduct a new TB prevalence survey in the region. The primary objective of the survey was to estimate the prevalence of bacteriologically positive TB patients amongst the adult population (>15 years) in a regional representative sample and to improve quality life of infected patients in the society and help RNTCP to devise new strategies to control TB in Kashmir valley, India.

Material and Methods

The present cross-sectional hospital-based study was conducted in the Department of Chest Medicine, CDH Government Medical College, Srinagar and IRL, STDC, CDH, Srinagar, India. After acquiring the formal ethical clearance from the Institutional Ethical Committee (IEC) of Government Medical College Srinagar under Ref No: 138/ETH/GMC/ICMR, and informed consent from the participants, the present study was conducted in Kashmir valley from March 2019 to December 2020 in 10 districts.

1. Anantnag and Kulgam (considered as one for the study)
2. Baramulla and Bandipora (considered as one for the study)
3. Pulwama and Shopian (considered as one for the study)
4. Srinagar and Ganderbal (considered as one for the study)
5. Budgam
6. Kupwara

Inclusion criteria: Patients older than 15 years were taken for study after getting due consent. Patients of Kashmiri ethnic origin. Samples which follow WHO standard were included.

Exclusion criteria: Patients of non Kashmiri origin. Patients less than 15 years of age. Samples which are not as per WHO standard were excluded.

Sample size calculation: The sample size was estimated based on WHO 2018 guidelines (2),(12),(13). The G power software tool, version 3.1 was used to calculate sample size.

A total of 66829 presumptive TB samples in 2019 (inclusive of 450 samples from CDH) and 63532 presumptive TB samples in 2020 (inclusive of 400 samples from CDH) were collected from Department of Chest Medicine, Government Medical College, Srinagar and RNTCP Centres of Kashmir valley district hospitals under State TB Office-Director Health Kashmir as per WHO criteria (14),(15). It included both the positive and negative cases of TB registered during the year 2019 and 2020. The total data of mid-year (mid-interval) population during the study period was estimated by using census 2011 figures and growth rates published in sample registration system bulletins (16),(17).

Prevalence was estimated as the:

Number of reported cases of TB/ Estimated mid-year (mid-interval) population × 100000

Study Procedure

The cross-sectional study consists of patient’s socio-demographic details and laboratory examinations. The participants having symptoms like cough >2 weeks, chest pain, fever more than two weeks, diabetes and age 15-65 years were taken for sputum examination and were asked to provide two sputum samples as per WHO criteria (18),(19),(20),(21),(22). The RNTCP staff collected one spot sputum sample in a pre numbered sterilised sputum cup. A second vial was provided for morning sample collection. For people living in difficult terrain, two spot samples were taken one hour apart and transported to the nearest Designated Microscopy Centre (DMC). X-ray examinations were done at the nearest facility and the suspicious X-ray reports were tested using Acid Fast Bacillus (AFB) staining and were further confirmed by advanced technologies of diagnostics i.e., Cartridge Based Nucleic acid Amplification Test (CBNAAT) and TrueNat. Patients who were found positive were given treatment at the nearest hospitals using Directly Observed Treatment Short-course (DOTS).
Statistical Analysis

The data obtained was evaluated using Microsoft Excel 2011 and then analysed in Statistical Package for the Social Sciences (SPSS) version 16.1 (Chicago IL). The p-values were calculated as percentage by Student’s t-test and Pearson’s correlation analysis. A p-value of <0.05 was considered statistically significant. Prevalence estimations and 95% Confidence Interval (CI) for smear- and bacteriologically positive TB were calculated as recommended.

Results

Between 2019 and 2020, 850 microscopic exams were performed at CD hospital Srinagar, which were included in regional data. Pulmonologists and clinicians examined 66,829 probable TB cases in the age group of 15-65 years in the ethnic community of Kashmir valley during the year 2019 (Table/Fig 1). There were 3692 people diagnosed with TB infection among them. While the demographics of the participants were examined using the student’s t-test, it was discovered that all of the participants have a relationship with demographics (age, gender, and residence) (p>0.05), which is statistically insignificant (Table/Fig 2). In bacteriologically, TB infected positive patients from Kashmir valley, there was no link between age, gender, or residence (p>0.05) (Table/Fig 3). As summarised in (Table/Fig 4), error-blot depicts the relationship of examined demographics in positive TB cases with 95% CI on AFB microscopy and molecular testing and (Table/Fig 5) is correlation analysed by Pearson’s correlation analysis which summarises with respect to demographics and positive tuberculosis rate which were insignificant where (p>0.05) (Table/Fig 6),(Table/Fig 7) shows that the frequency was highest in Srinagar district among the 10 districts throughout both years. According to the data, the decrease in the number of positive cases detected in 2020 as compared to 2019 was attributable to ongoing surveillance, pandemic of COVID-19. The Standard Operating Procedure (SOPs) including social distancing, use of face masks and use of sanitisers helped in decrease the transmission and incidence of TB which shows that these SOP’s (guidelines issued by WHO) can be used to reduce the transmission of TB.

In the year 2019, 1668 participants in the urban population were found to be TB infected, as confirmed by gold standard method (AFB, Ziehl-Neelsen staining microscopy) and molecular tests (CBNAAT/TrueNat), whereas 2024 participants in the rural population were found to be TB infected. The two key criteria studied to analyse the total prevalence were gender and region. In 2019, 1,955 males and 1737 females were infected with TB, according to gender distribution. In the Kashmir valley, the total prevalence of TB was found to be 49.03 per 100,000 people in 2019. In the Kashmir valley, 63,532 probable TB cases were assessed according to WHO criteria in the age category of 15-65 years in 2020. There were 2,839 people diagnosed with TB infection among them. In the year 2020, according to the distribution of habitation and gender, 1,123 participants in the urban population were TB infected as proven by microscopy and molecular tests, whereas 1,716 participants in the rural population were TB infected. In the year 2020, there were 1,472 males and 1,367 females affected, according to gender distribution. The total prevalence of TB analysed during the year 2020 was found to be 37.31 per 100,000 population in the Kashmir valley (Table/Fig 1).

Factor I: Total prevalence as per the regions (Rural/Urban)

The (Table/Fig 6) shows, in the year 2019, 66829 presumptive TB patients were seen in the Kashmir valley’s hospitals and RNTCP centres. Gold standard AFB Microscopy and Molecular tests (CBNAAT/TrueNat) revealed that 63137 subjects were negative and 3692 were positive. Srinagar district had 1668 positive TB cases with a prevalence rate of 101.53 per 100,000 people, followed by Anantnag district with 713 positive cases and a prevalence rate of 43.27 per 100,000 population according to data analysis of 10 districts in Kashmir valley. With 175 cases and a prevalence rate of 21.08 per 100,000 people, the Budgam district of Kashmir valley had the lowest prevalence.

The (Table/Fig 7), shows that in the year 2020, 63532 probable TB cases visited the Kashmir valley’s hospitals and RNTCP centres. The gold standard AFB Microscopy and Molecular testing (CBNAAT/TrueNat) identified 60693 subjects to be negative and 2839 to be positive. Srinagar district had 1123 positive TB cases with a prevalence rate of 67.79 per 100,000 people, followed by Kupwara district with 333 positive cases and a prevalence rate of 34.34 per 100,000 population according to data analysis of 10 districts in Kashmir valley. With 177 cases and a prevalence rate of 19.21 per 100,000 people, the Pulwama district of Kashmir valley had the lowest prevalence. The COVID-19 pandemic was to blame for the decrease in prevalence rate in 2020. Patients adopted WHO preventative measures such as social distancing and mask use, which may have lowered TB disease transmission and incidence rates. Due to the COVID-19 epidemic, fewer patients visited hospitals and health centres, resulting in fewer cases being screened.

Factor II: Age group

In 2019, the most afflicted districts were Srinagar, followed by Anantnag, and then Baramulla, with Budgam being the least affected district. Srinagar was again the most affected district in the year 2020, followed by Baramulla and Anantnag, and finally Kupwara. Budgam and Pulwama were the least hit areas (Table/Fig 8),(Table/Fig 9).

Factor III: Gender

Males were more impacted than females in Srinagar, according to a district-by-district TB case and gender-by-gender distribution in 2019. Similarly, males were impacted more than females in district Anantnag, but females were most affected in district Baramulla. In 2020, a map depicting district-by-district TB cases and gender-by-gender distribution revealed that males were more impacted than females in Srinagar. Males were also afflicted more than females in districts Anantnag and Kupwara, although females were most affected in district Baramulla (Table/Fig 10),(Table/Fig 11).

In all districts of Kashmir valley in both 2019 and 2020, the most TB cases were reported in the 15-30 age group, with the majority of cases reported from Srinagar city, followed by Baramulla. According to present study findings, Srinagar had the greatest number of TB cases in both male and female sexes, followed by Anantnag, and Budgam and Pulwama had the lowest. The (Table/Fig 12) depicts the condition in Kashmir valley with regard to Extrapulmonary TB (EPTB) and the number of positive cases projected in 2019 and 2020.

The (Table/Fig 13) clearly indicates here that the 17.72% of patients of urban population are TB positive in the year 2019 and whereas in (Table/Fig 14) reports that the 19.13% patients are TB positive in the urban population in the year 2020.

Discussion

This study enrolled 66829 presumptive TB samples in 2019 and 63532 presumptive TB samples in 2020, and it was a cross-sectional hospital-based study. The study was conducted to estimate the prevalence of TB in the Kashmir valley. Latest findings by the Rehman S et al., 2020 completed investigations on TB prevalence disease in the Kashmir valley (14). As per recent research study analysis in 2018, India accounted for 25% of the worldwide TB burden, with an estimated 2.8 million new cases (16). The Government of India, has set an ambitious goal of eliminating TB by 2025, well ahead of the 2030 sustainable development goals framework. In addition to implementing the National Strategic Plan to meet the goal, various additional initiatives have been launched, including notification of new cases to the government by private health providers, active case discovery, medication resistance surveys, and nutritional support for TB patients. The Ministry of Health, Government of India, has now initiated a countrywide TB prevalence survey to determine the disease’s prevalence at the national and subnational levels (16),(17). In this study, it was found that the prevalence of TB disease in the Kashmir valley was 49.03 per 100,000 people in 2019 and 37.31 per 100,000 people among 2020, which was consistent with other study done by Rehman S et al., 2020 in Kashmir’s ethnic community (14). The annual risk of infection in Delhi is 2.4% (state TB officer, Delhi, pers. comm.) (18).

Traditional approaches for tracing TB transmission are imprecise and ineffectual in controlling the disease, necessitating the use of molecular diagnostics, which aligns with present study research model. It is one among the world’s most deadly and widespread illnesses. The prevalence was highest in Srinagar and lowest in Budgam and Pulwama districts. This could indicate a higher prevalence of TB in the area, or a higher rate of case discovery and reporting, or both. Due to the COVID-19 pandemic and the WHO’s preventive initiatives, the prevalence rate of TB was found to be lower in 2020 than in 2019. TB has been designated as a global public health emergency. It is a major cause of morbidity and mortality, particularly in under-developed nations. Sputum smear positive cases are the most worrisome because they can spread the illness quickly and easily in the community through spitting. As a result, early detection and treatment are critical. The WHO’s goal for reducing the disease’s global burden includes early detection and treatment of such patients. This research looked into the TB condition in Kashmir in order to give a more accurate and realistic picture of the disease load in the valley. The age and sex were the main factors used to study the distribution in TB cases in Kashmir valley. The various studies reported on gender basis on different populations suggested that the males were highest predisposed to the disease as compared to females which was in line with other studies done in different ethical populations of the world like China, Cambodia, Ethiopia, Bangladesh, Pakistan etc., (19),(20),(21),(22). The study reported by Mushtaq MU et al., showed that the prevalence of TB increased with age; a similar pattern can be seen in Pakistan’s TB surveillance statistics (23). Rather than rapid transmission, the greater TB prevalence among the elderly could be explained by return of TB due to endogenous reactivation in combination with a weakened immune system (24),(25).

Limitation(s)

Every study has some limitations. In future course, more study will be taken with advanced molecular diagnostics with large sample size with clinical and laboratory parameters.

Conclusion

The study emphasises the significance of incorporating sophisticated diagnostic technology such as CBNAAT/TrueNat as a critical diagnostic tool for presumed positive TB cases in Kashmir. CBNAAT/TrueNat is a nucleic acid-based molecular biology cartridge approach that is more precise and accurate than sputum smear microscopy. Accurate estimates of the TB burden at the regional and national levels aid policy makers in developing strategies to combat the disease, reduce the country’s economic burden, and improve humanity’s health index by reducing disease co-morbidity.

Acknowledgement

The Principal/Dean Government Medical College Srinagar and Department of Chest Medicine GMC Srinagar are highly acknowledged for their support in the research and authors are thankful to all technical staff of CDH, STDC LAB and RNTCP, STO, staff of Kashmir for their help and kind support. Also thanks to patients for their participation in the study. Along with screening staff of RNTCP, Logistic and procurement Department of RNTCP Kashmir is doing great work and contribution to fight this disease as per government vision of end of TB upto 2025 30.

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DOI and Others

DOI: 10.7860/JCDR/2022/53062.15847

Date of Submission: Oct 28, 2021
Date of Peer Review: Nov 27, 2021
Date of Acceptance: Dec 14, 2021
Date of Publishing: Jan 01, 2022

AUTHOR DECLARATION:
• Financial or Other Competing Interests: None
• Was Ethics Committee Approval obtained for this study? Yes
• Was informed consent obtained from the subjects involved in the study? Yes
• For any images presented appropriate consent has been obtained from the subjects. No

PLAGIARISM CHECKING METHODS:
• Plagiarism X-checker: Oct 31, 2021
• Manual Googling: Dec 13, 2021
• iThenticate Software: Dec 24, 2021 (15%)

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