Guillain-Barré Syndrome Triggered by Tetanus Vaccination during Pregnancy: A Rare Case Report
Correspondence Address :
Dr. Prince Yadav,
PG Boys Hostel, C-55, Dr. D. Y. Patil Medical College and Hospital, Pune-411018, Maharashtra, India.
E-mail: princeera22@gmail.com
Guillain-Barré Syndrome (GBS) following tetanus immunisation during pregnancy is an extremely rare occurrence. GBS is an autoimmune disorder in which the immune system targets peripheral nerves, causing muscle weakness and in extreme cases, paralysis. GBS after vaccination, especially after the tetanus, diphtheria and pertussis (Tdap) vaccine, is extremely rare. Here, a case of 21-year-old woman (G2A1, gravida 2, abortion 1) with acute onset of bilateral symmetrical ascending paralysis with areflexia in both upper and lower limbs, with a prior history of Tetanus vaccination 15 days back is described. The patient was examined thoroughly and all other causes were ruled out. Management of this patient was challenging, as it required treating the GBS along with ensuring the wellbeing of the foetus. The aetiological diagnosis also posed a challenge, as there was no clear history of any incriminating cause. Intravenous Immunoglobulins (IVIG) and physiotherapy were given which led to an improvement in the patient's condition. Although the routine practices followed in pregnancy, like vaccination, is vital, this case highlights the potential complications of the same. Reporting such cases is essential to enhance understanding of vaccine safety and guide future recommendations. The clinical implications enforce the need for early diagnosis and prompt management to ensure favourable outcomes for both the mother and foetus.
Antenatal care, Autoimmune disease, Immunisation, Intravenous Immunoglobulins, Physiotherapy
DOI: 10.7860/JCDR/2025/75651.20489
Date of Submission: Sep 16, 2024
Date of Peer Review: Oct 16, 2024
Date of Acceptance: Nov 15, 2024
Date of Publishing: Jan 01, 2025
AUTHOR DECLARATION:
• Financial or Other Competing Interests: None
• Was informed consent obtained from the subjects involved in the study? Yes
• For any images presented appropriate consent has been obtained from the subjects. Yes
PLAGIARISM CHECKING METHODS:
• Plagiarism X-checker: Sep 20, 2024
• Manual Googling: Oct 23, 2024
• iThenticate Software: Nov 13, 2024 (5%)
ETYMOLOGY: Author Origin
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