
Phytotherapeutics for Wound Healing: A Systematic Review on Effectiveness of Indian Herbal Extracts in Rat Models
Correspondence Address :
Nitesh Laxman Shambharkar,
Shivam Vatika Mopka, Bilaspur-495006, Chhattisgarh, India.
E-mail: dr.niteshshambharkar70@gmail.com
Wound healing is a multifaceted process that encompasses a coordinated set of chemical and cellular events aimed at restoring the integrity of the skin and underlying tissues. Globally, many individuals turn to medicinal plants as an alternative therapy for this purpose. The present review focuses on evaluating the in-vivo wound healing activity of herbal plant extracts native to India, comparing them with povidone-iodine. Plant extracts show potential as promising wound healing agents due to their rich active compounds, wide availability and low risk of side-effects. Data were gathered from various sources, including scientific databases such as Google Scholar, PubMed and ScienceDirect. Keywords such as “wound healing,” “animal studies,” “herbal,” “Wistar albino rats,” “India,” and “Ayurvedic” were used to identify relevant articles, which were then analysed. The present review compiles data from articles published over the past 14 years on the in-vivo wound healing potential of medicinal plants in rats, with povidone-iodine consistently used as a reference in these studies. The findings highlight the potential of medicinal plants to contribute to drug discovery as effective wound healers, which may lead to the development of new, safe drug molecules. Further research is required, including novel formulations and targeted drug delivery systems, alongside clinical trials, to scientifically validate these findings and transition them from the laboratory to industry for broader societal benefit.
Haemostasis, Hydroxyproline, Wistar albino rats, Wound breaking strength
DOI: 10.7860/JCDR/2025/77491.21052
Date of Submission: Dec 23, 2024
Date of Peer Review: Jan 25, 2025
Date of Acceptance: Apr 26, 2025
Date of Publishing: Jun 01, 2025
AUTHOR DECLARATION:
• Financial or Other Competing Interests: None
• Was informed consent obtained from the subjects involved in the study? No
• For any images presented appropriate consent has been obtained from the subjects. NA
PLAGIARISM CHECKING METHODS:
• Plagiarism X-checker: Dec 24, 2024
• Manual Googling: Apr 22, 2025
• iThenticate Software: Apr 24, 2025 (1%)
ETYMOLOGY: Author Origin
EMENDATIONS: 7
- Emerging Sources Citation Index (Web of Science, thomsonreuters)
- Index Copernicus ICV 2017: 134.54
- Academic Search Complete Database
- Directory of Open Access Journals (DOAJ)
- Embase
- EBSCOhost
- Google Scholar
- HINARI Access to Research in Health Programme
- Indian Science Abstracts (ISA)
- Journal seek Database
- Popline (reproductive health literature)
- www.omnimedicalsearch.com