
A Study on Plasma Fibrinogen as a Risk Factor for Premature Acute Myocardial Infarction
Correspondence Address :
Dr. Vignessh Raveekumaran,
Assistant Professor, Department of General Medicine, Mahatma Gandhi Medical College and Research Institute, Sri Balaji Vidyapeeth (Deemed to be University), Puducherry-607402, India.
E-mail: vignesshravee@gmail.com
Introduction: Acute Myocardial Infarction (AMI), a significant coronary event, is increasingly prevalent among younger populations, presenting unique challenges in risk assessment and prevention. Premature AMI, defined as occurring before the age of 55, is often linked to non traditional risk factors such as elevated Plasma Fibrinogen (PFg), a key component in atherothrombosis and vascular inflammation.
Aim: To determine the prevalence of elevated PFg levels in premature AMI patients (<55 years) and evaluate its association with AMI among patients admitted to a tertiary care hospital in Puducherry, India.
Materials and Methods: A hospital-based case-control study was conducted in the Coronary Care Unit (CCU) and Intensive Care Units (ICU) under the Department of General Medicine at a tertiary care teaching hospital in rural Puducherry, India. Over 18 year among 112 patients: 56 with AMI (cases) and 56 age- and sex-matched controls without AMI. Data were collected through clinical evaluations, Electrocardiography (ECG), Echocardiography (ECHO) and biochemical assays. PFg levels were classified as normal (<340 mg/dL) or elevated (>340 mg/dL) and the associations with AMI were analysed.
Results: The mean PFg level in AMI patients was significantly higher (409±52.3 mg/dL) than that in controls (226±46.2 mg/dL) (p<0.001). Elevated PFg levels were observed in 48.2% of AMI patients, correlating strongly with traditional risk factors such as smoking and lipid abnormalities.
Conclusion: Elevated PFg is a significant risk factor for premature AMI. Incorporating PFg measurement into cardiovascular risk assessments could aid in the early identification and targeted intervention for this at-risk population.
Acute-phase reactants, Atherothrombosis, Premature myocardial infarction
DOI: 10.7860/JCDR/2025/78735.21099
Date of Submission: Feb 18, 2025
Date of Peer Review: Apr 04, 2025
Date of Acceptance: Apr 22, 2025
Date of Publishing: Jun 01, 2025
AUTHOR DECLARATION:
• Financial or Other Competing Interests: None
• Was Ethics Committee Approval obtained for this study? Yes
• Was informed consent obtained from the subjects involved in the study? Yes
• For any images presented appropriate consent has been obtained from the subjects. NA
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ETYMOLOGY: Author Origin
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