Case report
Vocal Cord Amyloidosis in a Middle-aged Female: A Rare Clinical Entity
Correspondence Address :
Dr. Pragati Shikha,
Junior Resident, Department of Otorhinolaryngology and Head and Neck Surgery, Jawahar Lal Nehru Medical College, Datta Meghe Institute of Higher Education and Research, Wardha, Maharashtra, India.
E-mail: pragati.shikha2103@gmail.com
Primary laryngeal amyloidosis is a rare disorder, accounting for approximately 1% of all benign laryngeal lesions. The authors, here, report the case of a 55-year-old female who presented to the Otorhinolaryngology Department with complaints of change in voice for the past 2-3 years. The patient described a gradual onset of hoarseness, strained quality, and fatigue of voice. Additionally, she experienced quivering, effortful phonation, and a relatively high pitch. Video-directed laryngoscopy revealed a polypoid or polypoid-like, reddish growth over the true vocal cords. A Contrast-Enhanced Computed Tomography (CECT) scan of the neck showed features suggestive of glottic and subglottic stenosis. The patient subsequently underwent microlaryngoscopy under general anaesthesia, and a unilateral excisional biopsy was taken from the lesion. Histopathological examination of a 20× section demonstrated Congo red positivity under polarised light, confirming the presence of amyloid deposits. A corresponding Haematoxylin and Eosin (H&E)-stained section (20×) showed proliferation of fibroblasts arranged in fascicles with areas of hyaline degeneration. Postoperatively, the patient was advised speech therapy, and at three weeks of follow-up, significant improvement in voice quality was noted. The present case highlights the rarity of primary laryngeal amyloidosis and underscores the importance of considering this diagnosis in patients presenting with long-standing hoarseness of voice. A multidisciplinary approach, including surgical excision, postoperative speech therapy, and long-term follow-up, is essential for achieving favourable outcomes and reducing recurrence rates.
Congo red, Fascicles, Fibroblasts, Laryngeal amyloidosis, Speech therapy
DOI: 10.7860/JCDR/2026/79645.23260
Date of Submission: Apr 09, 2025
Date of Peer Review: Jul 22, 2025
Date of Acceptance: Nov 20, 2025
Date of Publishing: May 01, 2026
AUTHOR DECLARATION:
• Financial or Other Competing Interests: None
• Was informed consent obtained from the subjects involved in the study? Yes
• For any images presented appropriate consent has been obtained from the subjects. Yes
PLAGIARISM CHECKING METHODS:
• Plagiarism X-checker: Apr 11, 2025
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ETYMOLOGY: Author Origin
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