Journal of Clinical and Diagnostic Research, ISSN - 0973 - 709X

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Dr Mohan Z Mani

"Thank you very much for having published my article in record time.I would like to compliment you and your entire staff for your promptness, courtesy, and willingness to be customer friendly, which is quite unusual.I was given your reference by a colleague in pathology,and was able to directly phone your editorial office for clarifications.I would particularly like to thank the publication managers and the Assistant Editor who were following up my article. I would also like to thank you for adjusting the money I paid initially into payment for my modified article,and refunding the balance.
I wish all success to your journal and look forward to sending you any suitable similar article in future"



Dr Mohan Z Mani,
Professor & Head,
Department of Dermatolgy,
Believers Church Medical College,
Thiruvalla, Kerala
On Sep 2018




Prof. Somashekhar Nimbalkar

"Over the last few years, we have published our research regularly in Journal of Clinical and Diagnostic Research. Having published in more than 20 high impact journals over the last five years including several high impact ones and reviewing articles for even more journals across my fields of interest, we value our published work in JCDR for their high standards in publishing scientific articles. The ease of submission, the rapid reviews in under a month, the high quality of their reviewers and keen attention to the final process of proofs and publication, ensure that there are no mistakes in the final article. We have been asked clarifications on several occasions and have been happy to provide them and it exemplifies the commitment to quality of the team at JCDR."



Prof. Somashekhar Nimbalkar
Head, Department of Pediatrics, Pramukhswami Medical College, Karamsad
Chairman, Research Group, Charutar Arogya Mandal, Karamsad
National Joint Coordinator - Advanced IAP NNF NRP Program
Ex-Member, Governing Body, National Neonatology Forum, New Delhi
Ex-President - National Neonatology Forum Gujarat State Chapter
Department of Pediatrics, Pramukhswami Medical College, Karamsad, Anand, Gujarat.
On Sep 2018




Dr. Kalyani R

"Journal of Clinical and Diagnostic Research is at present a well-known Indian originated scientific journal which started with a humble beginning. I have been associated with this journal since many years. I appreciate the Editor, Dr. Hemant Jain, for his constant effort in bringing up this journal to the present status right from the scratch. The journal is multidisciplinary. It encourages in publishing the scientific articles from postgraduates and also the beginners who start their career. At the same time the journal also caters for the high quality articles from specialty and super-specialty researchers. Hence it provides a platform for the scientist and researchers to publish. The other aspect of it is, the readers get the information regarding the most recent developments in science which can be used for teaching, research, treating patients and to some extent take preventive measures against certain diseases. The journal is contributing immensely to the society at national and international level."



Dr Kalyani R
Professor and Head
Department of Pathology
Sri Devaraj Urs Medical College
Sri Devaraj Urs Academy of Higher Education and Research , Kolar, Karnataka
On Sep 2018




Dr. Saumya Navit

"As a peer-reviewed journal, the Journal of Clinical and Diagnostic Research provides an opportunity to researchers, scientists and budding professionals to explore the developments in the field of medicine and dentistry and their varied specialities, thus extending our view on biological diversities of living species in relation to medicine.
‘Knowledge is treasure of a wise man.’ The free access of this journal provides an immense scope of learning for the both the old and the young in field of medicine and dentistry as well. The multidisciplinary nature of the journal makes it a better platform to absorb all that is being researched and developed. The publication process is systematic and professional. Online submission, publication and peer reviewing makes it a user-friendly journal.
As an experienced dentist and an academician, I proudly recommend this journal to the dental fraternity as a good quality open access platform for rapid communication of their cutting-edge research progress and discovery.
I wish JCDR a great success and I hope that journal will soar higher with the passing time."



Dr Saumya Navit
Professor and Head
Department of Pediatric Dentistry
Saraswati Dental College
Lucknow
On Sep 2018




Dr. Arunava Biswas

"My sincere attachment with JCDR as an author as well as reviewer is a learning experience . Their systematic approach in publication of article in various categories is really praiseworthy.
Their prompt and timely response to review's query and the manner in which they have set the reviewing process helps in extracting the best possible scientific writings for publication.
It's a honour and pride to be a part of the JCDR team. My very best wishes to JCDR and hope it will sparkle up above the sky as a high indexed journal in near future."



Dr. Arunava Biswas
MD, DM (Clinical Pharmacology)
Assistant Professor
Department of Pharmacology
Calcutta National Medical College & Hospital , Kolkata




Dr. C.S. Ramesh Babu
" Journal of Clinical and Diagnostic Research (JCDR) is a multi-specialty medical and dental journal publishing high quality research articles in almost all branches of medicine. The quality of printing of figures and tables is excellent and comparable to any International journal. An added advantage is nominal publication charges and monthly issue of the journal and more chances of an article being accepted for publication. Moreover being a multi-specialty journal an article concerning a particular specialty has a wider reach of readers of other related specialties also. As an author and reviewer for several years I find this Journal most suitable and highly recommend this Journal."
Best regards,
C.S. Ramesh Babu,
Associate Professor of Anatomy,
Muzaffarnagar Medical College,
Muzaffarnagar.
On Aug 2018




Dr. Arundhathi. S
"Journal of Clinical and Diagnostic Research (JCDR) is a reputed peer reviewed journal and is constantly involved in publishing high quality research articles related to medicine. Its been a great pleasure to be associated with this esteemed journal as a reviewer and as an author for a couple of years. The editorial board consists of many dedicated and reputed experts as its members and they are doing an appreciable work in guiding budding researchers. JCDR is doing a commendable job in scientific research by promoting excellent quality research & review articles and case reports & series. The reviewers provide appropriate suggestions that improve the quality of articles. I strongly recommend my fraternity to encourage JCDR by contributing their valuable research work in this widely accepted, user friendly journal. I hope my collaboration with JCDR will continue for a long time".



Dr. Arundhathi. S
MBBS, MD (Pathology),
Sanjay Gandhi institute of trauma and orthopedics,
Bengaluru.
On Aug 2018




Dr. Mamta Gupta,
"It gives me great pleasure to be associated with JCDR, since last 2-3 years. Since then I have authored, co-authored and reviewed about 25 articles in JCDR. I thank JCDR for giving me an opportunity to improve my own skills as an author and a reviewer.
It 's a multispecialty journal, publishing high quality articles. It gives a platform to the authors to publish their research work which can be available for everyone across the globe to read. The best thing about JCDR is that the full articles of all medical specialties are available as pdf/html for reading free of cost or without institutional subscription, which is not there for other journals. For those who have problem in writing manuscript or do statistical work, JCDR comes for their rescue.
The journal has a monthly publication and the articles are published quite fast. In time compared to other journals. The on-line first publication is also a great advantage and facility to review one's own articles before going to print. The response to any query and permission if required, is quite fast; this is quite commendable. I have a very good experience about seeking quick permission for quoting a photograph (Fig.) from a JCDR article for my chapter authored in an E book. I never thought it would be so easy. No hassles.
Reviewing articles is no less a pain staking process and requires in depth perception, knowledge about the topic for review. It requires time and concentration, yet I enjoy doing it. The JCDR website especially for the reviewers is quite user friendly. My suggestions for improving the journal is, more strict review process, so that only high quality articles are published. I find a a good number of articles in Obst. Gynae, hence, a new journal for this specialty titled JCDR-OG can be started. May be a bimonthly or quarterly publication to begin with. Only selected articles should find a place in it.
An yearly reward for the best article authored can also incentivize the authors. Though the process of finding the best article will be not be very easy. I do not know how reviewing process can be improved. If an article is being reviewed by two reviewers, then opinion of one can be communicated to the other or the final opinion of the editor can be communicated to the reviewer if requested for. This will help one’s reviewing skills.
My best wishes to Dr. Hemant Jain and all the editorial staff of JCDR for their untiring efforts to bring out this journal. I strongly recommend medical fraternity to publish their valuable research work in this esteemed journal, JCDR".



Dr. Mamta Gupta
Consultant
(Ex HOD Obs &Gynae, Hindu Rao Hospital and associated NDMC Medical College, Delhi)
Aug 2018




Dr. Rajendra Kumar Ghritlaharey

"I wish to thank Dr. Hemant Jain, Editor-in-Chief Journal of Clinical and Diagnostic Research (JCDR), for asking me to write up few words.
Writing is the representation of language in a textual medium i e; into the words and sentences on paper. Quality medical manuscript writing in particular, demands not only a high-quality research, but also requires accurate and concise communication of findings and conclusions, with adherence to particular journal guidelines. In medical field whether working in teaching, private, or in corporate institution, everyone wants to excel in his / her own field and get recognised by making manuscripts publication.


Authors are the souls of any journal, and deserve much respect. To publish a journal manuscripts are needed from authors. Authors have a great responsibility for producing facts of their work in terms of number and results truthfully and an individual honesty is expected from authors in this regards. Both ways its true "No authors-No manuscripts-No journals" and "No journals–No manuscripts–No authors". Reviewing a manuscript is also a very responsible and important task of any peer-reviewed journal and to be taken seriously. It needs knowledge on the subject, sincerity, honesty and determination. Although the process of reviewing a manuscript is a time consuming task butit is expected to give one's best remarks within the time frame of the journal.
Salient features of the JCDR: It is a biomedical, multidisciplinary (including all medical and dental specialities), e-journal, with wide scope and extensive author support. At the same time, a free text of manuscript is available in HTML and PDF format. There is fast growing authorship and readership with JCDR as this can be judged by the number of articles published in it i e; in Feb 2007 of its first issue, it contained 5 articles only, and now in its recent volume published in April 2011, it contained 67 manuscripts. This e-journal is fulfilling the commitments and objectives sincerely, (as stated by Editor-in-chief in his preface to first edition) i e; to encourage physicians through the internet, especially from the developing countries who witness a spectrum of disease and acquire a wealth of knowledge to publish their experiences to benefit the medical community in patients care. I also feel that many of us have work of substance, newer ideas, adequate clinical materials but poor in medical writing and hesitation to submit the work and need help. JCDR provides authors help in this regards.
Timely publication of journal: Publication of manuscripts and bringing out the issue in time is one of the positive aspects of JCDR and is possible with strong support team in terms of peer reviewers, proof reading, language check, computer operators, etc. This is one of the great reasons for authors to submit their work with JCDR. Another best part of JCDR is "Online first Publications" facilities available for the authors. This facility not only provides the prompt publications of the manuscripts but at the same time also early availability of the manuscripts for the readers.
Indexation and online availability: Indexation transforms the journal in some sense from its local ownership to the worldwide professional community and to the public.JCDR is indexed with Embase & EMbiology, Google Scholar, Index Copernicus, Chemical Abstracts Service, Journal seek Database, Indian Science Abstracts, to name few of them. Manuscriptspublished in JCDR are available on major search engines ie; google, yahoo, msn.
In the era of fast growing newer technologies, and in computer and internet friendly environment the manuscripts preparation, submission, review, revision, etc and all can be done and checked with a click from all corer of the world, at any time. Of course there is always a scope for improvement in every field and none is perfect. To progress, one needs to identify the areas of one's weakness and to strengthen them.
It is well said that "happy beginning is half done" and it fits perfectly with JCDR. It has grown considerably and I feel it has already grown up from its infancy to adolescence, achieving the status of standard online e-journal form Indian continent since its inception in Feb 2007. This had been made possible due to the efforts and the hard work put in it. The way the JCDR is improving with every new volume, with good quality original manuscripts, makes it a quality journal for readers. I must thank and congratulate Dr Hemant Jain, Editor-in-Chief JCDR and his team for their sincere efforts, dedication, and determination for making JCDR a fast growing journal.
Every one of us: authors, reviewers, editors, and publisher are responsible for enhancing the stature of the journal. I wish for a great success for JCDR."



Thanking you
With sincere regards
Dr. Rajendra Kumar Ghritlaharey, M.S., M. Ch., FAIS
Associate Professor,
Department of Paediatric Surgery, Gandhi Medical College & Associated
Kamla Nehru & Hamidia Hospitals Bhopal, Madhya Pradesh 462 001 (India)
E-mail: drrajendrak1@rediffmail.com
On May 11,2011




Dr. Shankar P.R.

"On looking back through my Gmail archives after being requested by the journal to write a short editorial about my experiences of publishing with the Journal of Clinical and Diagnostic Research (JCDR), I came across an e-mail from Dr. Hemant Jain, Editor, in March 2007, which introduced the new electronic journal. The main features of the journal which were outlined in the e-mail were extensive author support, cash rewards, the peer review process, and other salient features of the journal.
Over a span of over four years, we (I and my colleagues) have published around 25 articles in the journal. In this editorial, I plan to briefly discuss my experiences of publishing with JCDR and the strengths of the journal and to finally address the areas for improvement.
My experiences of publishing with JCDR: Overall, my experiences of publishing withJCDR have been positive. The best point about the journal is that it responds to queries from the author. This may seem to be simple and not too much to ask for, but unfortunately, many journals in the subcontinent and from many developing countries do not respond or they respond with a long delay to the queries from the authors 1. The reasons could be many, including lack of optimal secretarial and other support. Another problem with many journals is the slowness of the review process. Editorial processing and peer review can take anywhere between a year to two years with some journals. Also, some journals do not keep the contributors informed about the progress of the review process. Due to the long review process, the articles can lose their relevance and topicality. A major benefit with JCDR is the timeliness and promptness of its response. In Dr Jain's e-mail which was sent to me in 2007, before the introduction of the Pre-publishing system, he had stated that he had received my submission and that he would get back to me within seven days and he did!
Most of the manuscripts are published within 3 to 4 months of their submission if they are found to be suitable after the review process. JCDR is published bimonthly and the accepted articles were usually published in the next issue. Recently, due to the increased volume of the submissions, the review process has become slower and it ?? Section can take from 4 to 6 months for the articles to be reviewed. The journal has an extensive author support system and it has recently introduced a paid expedited review process. The journal also mentions the average time for processing the manuscript under different submission systems - regular submission and expedited review.
Strengths of the journal: The journal has an online first facility in which the accepted manuscripts may be published on the website before being included in a regular issue of the journal. This cuts down the time between their acceptance and the publication. The journal is indexed in many databases, though not in PubMed. The editorial board should now take steps to index the journal in PubMed. The journal has a system of notifying readers through e-mail when a new issue is released. Also, the articles are available in both the HTML and the PDF formats. I especially like the new and colorful page format of the journal. Also, the access statistics of the articles are available. The prepublication and the manuscript tracking system are also helpful for the authors.
Areas for improvement: In certain cases, I felt that the peer review process of the manuscripts was not up to international standards and that it should be strengthened. Also, the number of manuscripts in an issue is high and it may be difficult for readers to go through all of them. The journal can consider tightening of the peer review process and increasing the quality standards for the acceptance of the manuscripts. I faced occasional problems with the online manuscript submission (Pre-publishing) system, which have to be addressed.
Overall, the publishing process with JCDR has been smooth, quick and relatively hassle free and I can recommend other authors to consider the journal as an outlet for their work."



Dr. P. Ravi Shankar
KIST Medical College, P.O. Box 14142, Kathmandu, Nepal.
E-mail: ravi.dr.shankar@gmail.com
On April 2011
Anuradha

Dear team JCDR, I would like to thank you for the very professional and polite service provided by everyone at JCDR. While i have been in the field of writing and editing for sometime, this has been my first attempt in publishing a scientific paper.Thank you for hand-holding me through the process.


Dr. Anuradha
E-mail: anuradha2nittur@gmail.com
On Jan 2020

Important Notice

Case Series
Year : 2026 | Month : September | Volume : 20 | Issue : 9 | Page : PR04 - PR11 Full Version

Clinical Outcomes and Technical Considerations in the Surgical and Endovascular Management of Ascending Aortic and Aortic Arch Aneurysms: A Case Series


Published: September 1, 2026 | DOI: https://doi.org/10.7860/JCDR/2026/90383.24331
B Nembian Raja Rajan, Guruswamy Narayanan Prabhu, Srinath Damodaran, AS Hariharan, Sujit Velayudhan

1. Associate Professor, Department of Cardiothoracic and Vascular Surgery, SRM Medical College Hospital and Research Centre, Chennai, Tamil Nadu, India. 2. Consultant, Department of Cardiothoracic and Vascular Surgery, Sir Ivan Stedeford Hospital, Chennai, Tamil Nadu, India. 3. Consultant, Department of Cardiac Anaesthesia, SRM Global Hospitals, Chennai, Tamil Nadu, India. 4. Consultant, Department of Cardiothoracic and Vascular Surgery, Frontier Lifeline Hospital, Chennai, Tamil Nadu, India. 5. Consultant, Department of Cardiothoracic and Vascular Surgery, SRM Global Hospitals, Chennai, Tamil Nadu, India.

Correspondence Address :
B Nembian Raja Rajan,
601, B-Block Medical Staff Quarters, SRM Nagar, Potheri, Chennai-603203, Tamil Nadu, India.
E-mail: nembianr@srmist.edu.in

Abstract

Aneurysms of the ascending aorta and aortic arch represent one of the most surgically challenging domains in cardiothoracic practice. Contemporary management requires a hybrid strategy integrating conventional open surgery, staged procedures, and Thoracic Endovascular Aortic Repair (TEVAR). This case series presents the institutional experience with six patients who underwent diverse surgical and endovascular interventions for aortic aneurysmal disease, highlighting surgical technique, perioperative complexity, and clinical outcomes. Six patients (age range 30-65 years; four males, two females) presented with aortic pathologies including ascending aortic aneurysm, aortic arch aneurysm, descending thoracic aortic aneurysm, and chronic Type B aortic dissection. Procedures included Aortic Valve Replacement (AVR) with ascending aorta replacement (Dacron graft), total arch replacement with the elephant trunk technique followed by staged TEVAR, carotid artery debranching with staged TEVAR, hemiarch replacement with innominate artery re-implantation, and emergency aortic debranching with TEVAR for complicated dissection. Five of six patients were discharged in haemodynamically stable condition with satisfactory postoperative recovery and continued well-being confirmed at outpatient follow-up. One patient died due to retrograde Type A aortic dissection with coronary extension and cardiac tamponade on postoperative day 10. A multidisciplinary, heart-team-based approach with careful patient selection, staged procedural planning, and individualised intraoperative strategy achieves acceptable outcomes even in complex aortic pathologies. TEVAR combined with surgical debranching provides a viable hybrid alternative in high-risk patients. Mortality risk persists in retrograde dissection, underscoring the need for vigilant surveillance.

Keywords

Aortic dissection, Endovascular procedures, Heart valve prosthesis implantation, Thoracic aortic diseases, Treatment outcome

Aortic aneurysmal disease involving the ascending aorta and arch constitutes a significant proportion of cardiovascular surgical volume in tertiary care centres. The natural history of untreated thoracic aortic aneurysms is progressive dilatation culminating in rupture or dissection, with an annual risk of catastrophic complication estimated at 2-3% for aneurysms below 5 cm and exceeding 7% for those above 6 cm (1),(2). The surgical management of these lesions has evolved considerably over the past three decades, moving from purely open repairs under Deep Hypothermic Circulatory Arrest (DHCA) to sophisticated hybrid approaches combining open surgical debranching with Thoracic Endovascular Aortic Repair (TEVAR) (3).

The complexity of aortic arch surgery arises from the necessity of ensuring adequate cerebral protection, achieving complete exclusion of the aneurysmal segment, and managing concomitant pathologies such as valvular disease, coronary artery disease, chronic kidney disease, and pulmonary compromise. Total arch replacement with the elephant trunk technique, popularised by Borst HG et al., allows staged treatment of extensive thoracoabdominal aneurysms and has significantly improved outcomes in what was previously a uniformly lethal condition (4).

In Indian surgical practice, the epidemiological profile of aortic aneurysm patients differs from western cohorts, with a significant proportion attributable to rheumatic valvular disease, longstanding

poorly controlled hypertension, and late-presenting degenerative aneurysms (5). The management of these patients in a resource-conscious environment demands not only technical expertise but also judicious planning of staged versus single-stage approaches.

This case series from the Institute of Cardiac Sciences, SRM Medical College Hospital & Research Centre, Chennai, presents six patients with diverse aortic pathologies managed between 2023 and 2025. The clinical presentations, operative strategies, intraoperative challenges, and outcomes are described, with the intent of contributing institutional data to the growing body of evidence on hybrid and staged aortic repair in the Indian context.

Case Report

Case 1: Descending Aortic Arch Aneurysm- Staged Carotid Debranching and TEVAR

A 61-year-old male with Type 2 Diabetes Mellitus (T2DM) and Systemic Hypertension (SHTN), both of five years duration and on regular medication, presented with hoarseness of voice persisting for three months. The patient remained symptomatic at presentation, was under concurrent Ear, Nose and Throat (ENT) follow-up for the same complaint and on medication, with a Contrast-Enhanced Computed Tomography (CECT) of the neck planned for further evaluation; CT was undertaken in this context to evaluate the hoarseness alongside suspected mediastinal pathology. Evaluation revealed a partially thrombosed large saccular aneurysm of the aortic arch just distal to the origin of the left subclavian artery on CT aortogram. Additionally, the patient was found on this admission to have a single functioning left kidney secondary to a severely narrowed calibre of the right renal artery with a shrunken right kidney- a critical anatomical consideration for contrast-based procedures and renal preservation.

The CT cerebral angiography revealed mild age-related cerebral atrophy, a chronic infarct in the right gangliocapsular region, and chronic infarcts in the left thalamus and left hemi-pons, indicating pre-existing cerebrovascular disease. Pre-operative 2D echocardiography demonstrated a dilated aortic arch (4.2 cm), concentric Left Ventricular Hypertrophy (LVH), and preserved Left Ventricular Ejection Fraction (LVEF) of 60%. Coronary angiography confirmed normal coronaries. Nephrologist and Neuromedicine fitness were obtained in view of these co-morbidities.

After multidisciplinary heart team discussion, a two-stage procedure was planned. Stage I: right carotid to left carotid bypass followed by left carotid to left subclavian artery bypass under general anaesthesia was performed to ensure adequate cerebral and upper limb perfusion prior to endograft deployment (Table/Fig 1)a. Stage II: TEVAR under fluoroscopic guidance with vascular plug occlusion of the origin of the left subclavian artery, successfully excluding the aneurysmal sac (Table/Fig 1)b, (Table/Fig 1)c. Intraoperative blood loss was approximately 300 mL, with one unit of Packed Red Blood Cells (PRBC) transfused.

Postoperatively, the patient was shifted to the Cardiothoracic and Vascular Surgery Intensive Care Unit (CTVS ICU) in haemodynamically stable condition. Neck Doppler on Post-operative Day 1 (POD-1) confirmed satisfactory flow through the bypass grafts. The patient was extubated, shifted to the ward on POD-3, and made a gradual uneventful recovery. He was discharged on POD-10 in stable condition and remains asymptomatic on outpatient follow-up.

Case 2: Ascending Aortic and Innominate Artery Aneurysm - Redo Sternotomy with Hemiarch Replacement

A 30-year-old male with a history of Aortic Valve Replacement (AVR) in March 2011 and SHTN was found to have a dilated ascending aorta (4.94 cm) on routine echocardiographic follow-up. He was asymptomatic, with no chest pain, dyspnoea, palpitations, or syncope. Physical examination revealed a valve click. Pre-operative echocardiography demonstrated a functioning mechanical prosthetic valve with a peak gradient of 32 mmHg, trivial paravalvular regurgitation, concentric LVH, and LVEF of 67%. CT aortogram confirmed increased calibre of the ascending aorta and proximal arch, consistent with post-regurgitation dilatation, and also identified an innominate artery aneurysm (Table/Fig 2)a.

The operative challenge in this case was substantial: redo median sternotomy carries significantly higher risk due to pericardial adhesions, risk of injury to patent bypass grafts or the prosthetic valve, and difficult haemostasis. The patient’s pre-existing oral anticoagulation (Tablet Acitrom 2 mg daily for the mechanical prosthesis) was bridged with intravenous heparin in the immediate pre-operative period; heparin was discontinued prior to surgery, and anticoagulation was reinstituted with Acitrom postoperatively once haemostasis was secure. Protamine was administered intraoperatively for heparin reversal following cardiopulmonary bypass. After thorough pre-operative planning and anaesthetic optimisation including hypertension control, the patient underwent ascending aorta and hemiarch replacement with innominate artery re-implantation through redo median sternotomy (Table/Fig 2)b, (Table/Fig 2)c, performed under systemic cooling to 24°C with a total circulatory arrest time of 55 seconds and retrograde cerebral perfusion delivered over two cycles (18 minutes). Cardiopulmonary bypass time was 189 minutes, with an aortic cross-clamp time of 134 minutes.

Neurological monitoring was performed intraoperatively using Near-Infrared Spectroscopy (NIRS). Intraoperative blood loss was approximately 300 mL, with two units of PRBC and two units of Fresh Frozen Plasma (FFP) transfused. The patient was extubated on POD-1, and the Intercostal Chest Drain (ICD) was removed on POD-3. In view of an elevated total leucocyte count, antibiotics were escalated to Injection Meropenem and Injection Targocid. The patient was ambulated on POD-2 and completed an uneventful recovery. Postoperative echocardiography confirmed a well-functioning mechanical prosthetic valve with a mean gradient of 7 mmHg, no periprosthetic graft leak, and preserved LV function (Ejection Fraction (EF) 60%). He was discharged on POD-9 and remains under regular outpatient surveillance in good health.

Case 3: Severe Aortic Stenosis with Dilated Ascending Aorta- AVR and Ascending Aorta Replacement

A 52-year-old female with rheumatic heart disease of 36 years’ duration and severe aortic stenosis presented with shortness of breath and palpitations. She was on regular medications and was referred for AVR. Pre-operative echocardiography demonstrated a calcified aortic valve with severe aortic stenosis (peak gradient 79 mmHg, mean gradient 53 mmHg), a bicuspid aortic valve, dilated ascending aorta of 4.2 cm, concentric LVH, and preserved LVEF of 65%. CT aortogram confirmed post-stenotic dilatation of the ascending aorta, proximal arch, and brachiocephalic artery. Coronary angiography showed normal epicardial coronaries.

Surgery was performed through median sternotomy with a cardiopulmonary bypass time of 130 minutes and an aortic cross-clamp time of 102 minutes. Intraoperative findings revealed severe cardiomegaly (3+), marked LV hypertrophy, a bicuspid aortic valve with severe calcification and commissural fusion, and a dilated ascending aorta measuring 6 cm with an unhealthy aortic wall (Table/Fig 3)a necessitating aorta replacement. AVR was performed with a 19 mm bioprosthetic valve using horizontal mattress intermittent sutures, and the ascending aorta was replaced with a 22 mm Dacron straight graft using end-to-end anastomosis (Table/Fig 3)b under standard cardiopulmonary bypass with antegrade cardioplegia and topical ice slush. Intraoperative Transoesophageal Echocardiography (TEE) confirmed good LVEF and no paravalvular leak. Intraoperative blood loss was approximately 200 mL, with no blood product transfusion required.

The patient was extubated on POD-1 and drains were removed on POD-2. Postoperative echocardiography confirmed a well-seated bioprosthetic valve with no leak (peak gradient 26 mmHg, mean gradient 12 mmHg), normal LV systolic function (EF 62%), and no pericardial effusion. She was discharged on postoperative day 12 in haemodynamically stable condition with a healthy wound and has continued well on outpatient follow-up.

Case 4: Severe Aortic Regurgitation with Ascending Aortic Dilatation- AVR and Aorta Replacement

A 65-year-old male with systemic hypertension presented with severe aortic regurgitation, mild aortic stenosis, and a markedly dilated ascending aorta measuring 6.60 cm on echocardiography. He complained of dyspnoea and palpitations. Pre-operative echocardiography confirmed moderate-to-severe aortic regurgitation (LVEF 62%), mild pulmonary hypertension, and grade I diastolic dysfunction. CT aortogram confirmed aneurysmal dilatation of the ascending aorta (Table/Fig 4)a. Coronary angiography showed normal epicardial coronary arteries.

Surgery was performed through median sternotomy with systemic cooling to 28°C, a cardiopulmonary bypass time of 154 minutes, and an aortic cross-clamp time of 108 minutes. The ascending aorta was transected; intraoperative findings confirmed a severely dilated, unhealthy aortic wall (6 cm) mandating aortic replacement. The aortic valve showed thickened, rolled-out leaflets with commissural fusion and severe calcification. AVR was performed with a 21 mm bioprosthetic valve, and the ascending aorta was replaced with a 24 mm Dacron straight graft (Table/Fig 4)b. Intraoperative TEE confirmed satisfactory valve function and no paravalvular leak. Intraoperative estimated blood loss was 600 mL, with two units of PRBC, four units of FFP, and four units of platelets transfused.

On POD-3, the patient developed new-onset atrial fibrillation with rapid ventricular response, which was successfully cardioverted pharmacologically with Injection Amiodarone 150 mg bolus. Postoperative echocardiography confirmed normal prosthetic valve function (peak gradient 20 mmHg, mean gradient 13 mmHg), preserved LV systolic function (EF 60%), and no paravalvular leak. The remainder of the hospital course was uneventful. He was discharged on POD-11 in stable condition and has continued well on outpatient review.


Case 5: Giant Aortic Arch and Descending Thoracic Aortic Aneurysm- Elephant Trunk Procedure and Staged TEVAR

A 64-year-old male with a 30-year smoking history, and SHTN and Chronic Obstructive Pulmonary Disease (COPD) each of 30 years duration, presented with progressive shortness of breath of two months duration. Imaging revealed a giant aneurysm of the aortic arch (diameter 8 cm and length 9 cm) with partial eccentric thrombus and a separate aneurysm of the descending thoracic aorta (diameter 10 cm and length 9 cm), also with eccentric thrombus, without evidence of aortic dissection (Table/Fig 5)a. An incidental fusiform aneurysm of the left common iliac artery was also identified.

Pre-operative Pulmonary Function Testing (PFT) demonstrated mild restriction, and CT chest confirmed centrilobular emphysematous changes predominantly in the upper lobes.

In view of the anatomical complexity (giant arch and descending thoracic aortic aneurysm), a two-stage hybrid approach was planned. Stage I: total arch replacement and ascending aortic replacement using the Elephant Trunk technique through median sternotomy (Table/Fig 5)b A procedure that deploys a free-floating graft segment (‘trunk’) into the descending aorta as a landing zone for subsequent TEVAR. The frozen elephant trunk technique was not employed in this case; the conventional elephant trunk approach was selected to allow staged completion once the patient’s pulmonary status, optimised pre-operatively in view of his COPD, permitted a second procedure. Stage I was performed with an aortic cross-clamp time of 175 minutes and a total circulatory arrest time of 65 minutes.

The postoperative course was demanding; on POD-1 the patient developed Generalised Tonic-Clonic Seizures (GTCS) requiring anti-epileptic therapy as per neurology guidance. CECT cerebral angiography performed to characterise the aetiology showed bilateral intracranial internal carotid, anterior, middle and posterior cerebral, and basilar arteries of normal calibre with no stenosis or vascular malformation; the anterior and posterior communicating arteries appeared normal, and the A1 segment of the right anterior cerebral artery was hypoplastic. No acute territorial infarction, haemorrhage, or space-occupying lesion was identified, and the study was reported as a normal cerebral angiogram- favouring a metabolic or hypoperfusion-related rather than embolic or structural aetiology for the seizure episode, though clinical correlation was advised. Pulmonology input was obtained for early Acute Respiratory Distress Syndrome (ARDS) prevention. The patient required tracheostomy on day 6 for prolonged mechanical ventilation. Post-operative CT aortogram confirmed an intact arch graft with no leak and a partially thrombosed descending thoracic aortic aneurysm. Intraoperative blood loss for Stage I was approximately 450 mL, with one unit of PRBC, two units of FFP, and two units of platelets transfused.

After clinical stabilisation, Stage II: TEVAR was performed via right femoral artery cutdown (Table/Fig 5)c. A Medtronic Valiant Thoracic Captiva endograft (36 mm diameter × 207 mm length) was deployed across the descending thoracic aortic aneurysm using Lunderquist extra-stiff wire guidance, meticulously avoiding celiac trunk occlusion. Post-deployment aortogram confirmed good stent opposition with no endoleak and no major arterial occlusion (Table/Fig 5)d.

The patient subsequently weaned off ventilation, was decannulated, and orthostatic hypotension was managed with Midodrine. He was discharged on day 29 in stable condition. Left common iliac aneurysm repair was deferred to a subsequent planned procedure. He remains well on follow-up.

Case 6: Chronic Type B Aortic Dissection with Penetrating Atherosclerotic Ulcer (PAU) - Hybrid TEVAR (Fatal Outcome)

A 58-year-old female presented with left-sided chest pain radiating to the upper back for three months, associated with approximately 5 kg of weight loss and episodic fever. She had been evaluated at a local hospital, where a diagnosis of Type B aortic dissection with proximal thoracic aortic dilatation, additional dissection at the left renal artery, PAU of the left subclavian artery and descending thoracic aorta, and a bovine aortic arch configuration was established. The patient discharged herself against medical advice and presented to the outpatient department for further management.

On admission, cardiac evaluation confirmed Type B aortic dissection with a flap in the false lumen extending beyond the left subclavian artery with a bovine arch. The patient developed fever spikes; urine culture grew Enterococcus species, and appropriate culture-sensitive antibiotics were commenced in consultation with the Infectious Diseases team. CT Kidney Ureter Bladder (KUB) revealed a small left kidney with cortical scarring. Pre-procedural CT cerebral angiography identified a small outpouching from the left subclavian artery and confirmed the bovine arch configuration. Following haematological optimisation with intravenous iron for anaemia, the multidisciplinary heart team approved a staged hybrid approach (Table/Fig 6)a.

Stage I: Aortic arch debranching—left subclavian artery to left common carotid artery bypass (Table/Fig 6)b was performed in the catheterisation laboratory under general anaesthesia after coronary angiography confirmed normal epicardial coronaries. The procedure was uneventful.

Stage II: TEVAR was performed on postoperative day 3 following the debranching procedure (Table/Fig 6)c, under general anaesthesia, and was uneventful. The patient was extubated and mobilised bedside with haemodynamic stability.

On postoperative day 8 following TEVAR (POD-11 overall, calculated from the Stage I debranching procedure), the patient developed sudden ptosis and left upper and lower limb weakness. CT brain confirmed small bilateral lacunar infarcts in the internal capsule region. CT neck and cerebral angiography revealed markedly reduced flow in the right common carotid and vertebral arteries with intimal dissection, and aortic intimal dissection suggesting aneurysmal changes- a pattern consistent with retrograde Type A extension. Repeat echocardiography at 09:00 hours confirmed a new dissection flap in the ascending aorta extending to the aortic root with moderate aortic regurgitation and preserved ejection fraction. Emergency surgical intervention (ascending aortic repair/Bentall procedure) was planned. However, at 12:30 hours while transferring to the cardiac operation theatre, the patient developed sudden bradycardia and profound hypotension. Emergency sternotomy was performed; pericardiocentesis revealed 500 g of clot consistent with cardiac tamponade. A 1.5×1.5 cm rent was identified at the posterior aspect of the aortic root. Despite 45 minutes of intracardiac massage and multiple defibrillation attempts, Return of Spontaneous Circulation (ROSC) could not be achieved. The patient was declared clinically dead. Intraoperative blood loss prior to the terminal event was approximately 150 mL, with one unit of PRBC transfused. Cause of death was Type A aortic dissection with coronary extension and cardiac tamponade in a postoperative case of TEVAR with left subclavian debranching for chronic Type B aortic dissection.

Summary of all the cases is presented in (Table/Fig 7).

Discussion

This case series illustrates the breadth of aortic aneurysmal pathology encountered in a tertiary cardiac centre and the requirement for individualised, multidisciplinary management strategies. The six cases collectively represent ascending aortic aneurysm with concomitant valvular disease, aortic arch aneurysm managed by debranching and TEVAR, total arch reconstruction with the Elephant Trunk technique, and complicated Type B dissection treated by hybrid endovascular repair.

Ascending aortic aneurysms in association with valvular disease- whether stenosis or regurgitation- represent the most commonly encountered combination in this series, as reflected by Cases 3 and 4. According to the American College of Cardiology/American Heart Association (ACC/AHA) and European Society of Cardiology (ESC) guidelines concurrent aortic root/ascending aorta replacement is recommended, at the time of aortic valve surgery when the aortic diameter exceeds 4.5 cm in the presence of bicuspid aortic valve or 5.0 cm in degenerative tricuspid disease [6,7]. Both patients in this series exceeded these thresholds at surgery, with intraoperative findings of unhealthy aortic walls and severe calcification confirming the appropriateness of concomitant repair. Aortic root reconstruction during valve surgery is associated with increased operative risk (8).

The Elephant Trunk procedure employed in Case 5 is a well-established technique for the management of extensive thoracoabdominal aneurysms. First described by Borst HG et al., in 1983 and subsequently refined by multiple groups, it allows total arch reconstruction at Stage I while providing a landing zone in the descending aorta for Stage II endovascular completion (4),(9). Postoperative neurological complications are recognised following proximal aortic surgery, with temporary neurological dysfunction and stroke reported in 5.9% and 4.3% of patients, respectively (10). In this case, a structurally normal cerebral angiogram favoured a metabolic or hypoperfusion mechanism over an embolic or structural one. Its management with anti-epileptic therapy and prolonged ventilatory support until neurological clarity was achieved represents standard practice. The need for tracheostomy highlights the importance of pulmonary rehabilitation protocols, especially given this patient’s pre-existing COPD. His ultimate recovery and successful Stage II TEVAR completion is a testament to the multidisciplinary critical care management achievable even in physiologically compromised patients.

The hybrid debranching-TEVAR approach employed in Case 1 is particularly relevant in the Indian context, where patients may present with complex anatomy, significant co-morbodities, or high operative risk for total arch replacement. This is consistent with the findings of Sai Krishna C et al., who, in their single-centre Indian experience, similarly emphasised staged and hybrid strategies to extend aortic repair to high-risk patients unsuitable for conventional open total arch surgery. Despite a patient population with substantial comorbidities, they reported outcomes broadly comparable to those observed in the present case series (5). Carotid-to-carotid and carotid-to-subclavian bypasses, followed by TEVAR with vascular plug occlusion of the origin of the revascularised vessel, allow complete exclusion of arch aneurysms with reduced physiological insult compared to open arch repair (11),(12). The importance of pre-operative Doppler confirmation of graft flow, as performed in this case, is a critical quality check that should be part of the standardised postoperative pathway.

Case 2 presented a unique technical challenge: ascending aortic aneurysm with innominate artery involvement requiring hemiarch replacement via redo sternotomy in a young patient with a prior mechanical AVR. Reoperative valve replacement is associated with an increased operative risk, with mortality influenced by the type and urgency of reoperation (13). The use of intraoperative NIRS for cerebral monitoring, defined circulatory arrest and retrograde cerebral perfusion parameters, and judicious peri-operative heparin bridging of the patient’s mechanical-valve anticoagulation were critical elements of this case. The excellent neurological and haemodynamic outcome achieved in this young patient underscores the value of detailed pre-operative planning and experienced operative execution.

The fatal outcome in Case 6 illustrates the most feared complication following TEVAR for Type B aortic dissection—retrograde Type A aortic dissection (RTAD). This complication, reported in 1.3-2.5% of TEVAR procedures for Type B dissection, arises from traumatic injury to the aortic intima at the proximal landing zone of the endograft, propagating retrogradely into the ascending aorta and aortic root (14),(15). Risk factors include extensive dissection, inadequate proximal landing zone, high oversizing of the graft, and inherent aortic fragility. In the present case, the combination of a bovine aortic arch, a PAU, chronic dissection, and pre-existing systemic infection likely contributed to aortic wall vulnerability. The progression from neurological deficits to cardiac tamponade within hours exemplifies the fulminant natural history of this complication. Prompt echocardiographic surveillance and a low threshold for emergency re-operation are mandatory; however, even with optimal response, outcomes remain dismal once aortic root rupture has occurred (16).

The outcomes of the present series, comprising five successful discharges and one death due to a recognised complication, are comparable with outcomes reported in an Indian single-centre experience of aortic aneurysm surgery [5,17]. The mortality rate of 16.7% (1/6) in a cohort enriched with complex re-operative, hybrid, and emergent procedures is contextually acceptable, though every effort must be made to further reduce this through refined patient selection, improved endograft technology, and standardised surveillance protocols. Within this series, the Indian context manifested concretely in patient-level factors rather than only as a backdrop: rheumatic valvular involvement in a relatively young patient (Case 3), prolonged, often-delayed disease courses prior to definitive referral (Cases 1, 3 and 6), and resource-conscious staged strategies adopted specifically to extend repair to patients who would otherwise be deemed unfit for single-stage open total arch surgery.

Several lessons emerge from this series. First, meticulous preoperative imaging with multi-modality assessment (echocardiography, CT aortogram, cerebral angiography, Doppler studies) is non negotiable in all aortic aneurysm patients. Second, a heart team approach incorporating cardiology, cardiac surgery, cardiac anaesthesia, neurology, nephrology, and intensive care is essential for complex cases. Third, staged procedures- whether open followed by TEVAR or debranching followed by TEVAR- allow optimisation of physiological reserve between stages, reducing cumulative operative risk. Fourth, post-TEVAR surveillance with echocardiography and cross-sectional imaging must be vigilant, particularly in the early postoperative period when retrograde dissection risk is highest.

Conclusion

The present institutional case series demonstrates that a wide spectrum of ascending aortic and aortic arch aneurysmal pathologies can be successfully managed through individualised surgical and hybrid endovascular strategies in a dedicated cardiac surgical programme. Open AVR with concomitant ascending aortic replacement, total arch reconstruction using the Elephant Trunk procedure with staged TEVAR, and hybrid carotid debranching with TEVAR each address distinct anatomical and physiological challenges. Multidisciplinary planning, meticulous surgical execution, and comprehensive postoperative monitoring collectively drive favourable outcomes. Retrograde Type A dissection following TEVAR for Type B disease remains a life-threatening complication demanding immediate recognition and intervention. Continued accumulation of institutional data and contribution to national registry efforts are essential to refine guidelines for aortic surgery in the Indian patient population.

References

1.
Elefteriades JA. Natural history of thoracic aortic aneurysms: Indications for surgery, and surgical versus nonsurgical risks. Ann Thorac Surg. 2002;74(5):S1877-S1880. [crossref] [PubMed]
2.
Davies RR, Goldstein LJ, Coady MA, Tittle SL, Rizzo JA, Kopf GS, et al. Yearly rupture or dissection rates for thoracic aortic aneurysms: Simple prediction based on size. Ann Thorac Surg. 2002;73(1):17-28. [crossref] [PubMed]
3.
Coselli JS, LeMaire SA, Preventza O, de la Cruz KI, Cooley DA, Price MD, et al. Outcomes of 3309 thoracoabdominal aortic aneurysm repairs. J Thorac Cardiovasc Surg. 2016;151(5):1323-38. [crossref] [PubMed]
4.
Borst HG, Walterbusch G, Schaps D. Extensive aortic replacement using ‘elephant trunk’ prosthesis. Thorac Cardiovasc Surg. 1983;31(1):37-40. [crossref] [PubMed]
5.
Sai Krishna C, Bhaskararao GV, Balakrishnan KR. Aortic aneurysm surgery in India: Patterns and outcomes in a single-centre experience. Indian J Thorac Cardiovasc Surg. 2018;34(3):280-87.
6.
Writing Committee Members; Isselbacher EM, Preventza O, Hamilton Black J 3rd, Augoustides JG, Beck AW, Bolen MA, et al. 2022 ACC/AHA guideline for the diagnosis and management of aortic disease: A report of the American Heart Association/American College of Cardiology Joint Committee on Clinical Practice Guidelines. J Thorac Cardiovasc Surg. 2023;166(5):e182-e331. Doi: 10.1016/j.jtcvs.2023.04.023. Epub 2023 Jun 28. PMID: 37389507; PMCID: PMC10784847.
7.
Erbel R, Aboyans V, Boileau C, Bossone E, Bartolomeo RD, Eggebrecht H, et al; ESC Committee for Practice Guidelines. 2014 ESC Guidelines on the diagnosis and treatment of aortic diseases: Document covering acute and chronic aortic diseases of the thoracic and abdominal aorta of the adult. The Task Force for the Diagnosis and Treatment of Aortic Diseases of the European Society of Cardiology (ESC). Eur Heart J. 2014;35(41):2873-926. Doi: 10.1093/eurheartj/ ehu281. Epub 2014 Aug 29. Erratum in: Eur Heart J. 2015;36(41):2779. Doi: 10.1093/eurheartj/ehv178. PMID: 25173340. [crossref] [PubMed]
8.
Rankin JS, Hammill BG, Ferguson TB Jr, Glower DD, O’Brien SM, DeLong ER, et al. Determinants of operative mortality in valvular heart surgery. J Thorac Cardiovasc Surg. 2006;131(3):547-57. [crossref] [PubMed]
9.
Svensson LG, Kim KH, Blackstone EH, Alster JM, McCarthy PM, Greenberg RK, et al. Elephant trunk procedure: Newer indications and uses. Ann Thorac Surg. 2004;78(1):109-16; discussion 109-16. Doi: 10.1016/j.athoracsur.2004.02.098. PMID: 15223413. [crossref] [PubMed]
10.
Halkos ME, Kerendi F, Myung R, Kilgo P, Puskas JD, Chen EP. Selective antegrade cerebral perfusion via right axillary artery cannulation reduces morbidity and mortality after proximal aortic surgery. J Thorac Cardiovasc Surg. 2009;138(5):1081-89. [crossref] [PubMed]
11.
Czerny M, Weigang E, Sodeck G, Schmidli J, Antona C, Gelpi G, et al. Targeting landing zone 0 by total arch rerouting and TEVAR: Midterm results of a transcontinental registry. Ann Thorac Surg. 2012;94(1):84-89. Doi: 10.1016/j. athoracsur.2012.03.024. Epub 2012 May 16. PMID: 22595468. [crossref] [PubMed]
12.
Canaud L, Alric P, Laurent M, Baum TP, Branchereau P, Marty-Ané CH, et al. Proximal fixation of thoracic stent-grafts as a function of oversizing and increasing aortic arch angulation in human cadaveric aortas. J Endovasc Ther. 2008;15(3):326-34. [crossref] [PubMed]
13.
Akins CW, Buckley MJ, Daggett WM, Hilgenberg AD, Vlahakes GJ, Torchiana DF, et al. Risk of reoperative valve replacement for failed mitral and aortic bioprostheses. Ann Thorac Surg. 1998;65(6):1545-51; discussion 1551-2. Doi: 10.1016/s0003-4975(98)00301-4. PMID: 9647056. [crossref] [PubMed]
14.
Chen Y, Zhang S, Liu L, Lu Q, Zhang T, Jing Z. Retrograde Type A aortic dissection after thoracic endovascular aortic repair: A systematic review and meta-analysis. J Am Heart Assoc. 2017;6(9):e004649. Doi: 10.1161/JAHA.116.004649. PMID: 28939705; PMCID: PMC5634245. [crossref] [PubMed]
15.
Eggebrecht H, Thompson M, Rousseau H, Czerny M, Lönn L, Mehta RH, et al. Retrograde ascending aortic dissection during or after thoracic aortic stent graft placement. Circulation. 2009;120(11 Suppl):S276-S281. [crossref]
16.
Fattori R, Montgomery D, Lovato L, Kische S, Di Eusanio M, Ince H, et al. Survival after endovascular therapy in patients with type B aortic dissection: A report from the International Registry of Acute Aortic Dissection (IRAD). JACC Cardiovasc Interv. 2013;6(8):876-82. Doi: 10.1016/j.jcin.2013.05.003. PMID: 23968705. [crossref] [PubMed]
17.
Tiwari KK, Murzi M, Bevilacqua S, Glauber M. Which cannulation (ascending aortic cannulation or peripheral arterial cannulation) is better for acute type A aortic dissection surgery? Interact Cardiovasc Thorac Surg. 2010;10(5):797-802 [crossref]. [PubMed]

DOI and Others

DOI: 10.7860/JCDR/2026/90383.24331

Date of Submission: May 09, 2026
Date of Peer Review: Jun 12, 2026
Date of Acceptance: Jul 08, 2026
Date of Publishing: Sep 01, 2026

AUTHOR DECLARATION:
• Financial or Other Competing Interests: None
• Was informed consent obtained from the subjects involved in the study? Yes
• For any images presented appropriate consent has been obtained from the subjects. Yes

PLAGIARISM CHECKING METHODS:
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ETYMOLOGY: Author Origin

EMENDATIONS: 6

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