Year :
2021
| Month :
February
| Volume :
15
| Issue :
2
| Page :
OC33 - OC37
Full Version
Lack of Excess Cardiovascular Risks among First Degree Relatives of Persons with Diabetes Mellitus: Is Lifestyle the Cause?
Published: February 1, 2021 | DOI: https://doi.org/10.7860/JCDR/2021/44775.14566
Taiwo H Raimi, Bolade Folasade Dele-Ojo, Samuel A Dada, Joseph O Fadare
1. Lecturer/Consultant Physician, Department of Medicine, Ekiti State University/Ekiti State University Teaching Hospital, Ado-Ekiti, Ekiti, Nigeria.
2. Lecturer/Consultant Physician, Department of Medicine, Ekiti State University/Ekiti State University Teaching Hospital, Ado-Ekiti, Ekiti, Nigeria.
3. Lecturer/Consultant Physician, Department of Medicine, Ekiti State University/Ekiti State University Teaching Hospital, Ado-Ekiti, Ekiti, Nigeria.
4. Associate Professor/Consultant Physician, Department of Pharmacology/Therapeutics and Medicine, Ekiti State University/Ekiti State University Teaching Hospital,
Ado-Ekiti, Ekiti, Nigeria.
Correspondence Address :
Dr. Taiwo H Raimi,
Department of Medicine, Ekiti State University/Ekiti State University Teaching Hospital,
Ado-Ekiti, Ekiti State, Nigeria.
E-mail : taiwo.raimi@eksu.edu.ng
Abstract
Introduction: The prevalence of Diabetes Mellitus (DM) is rising worldwide with a projected increase of more than 50% in next three decades. Family History of Diabetes (FHD) is a recognised risk factor for DM, but development of DM in relatives of people with the disease, who carry susceptible genes, is dependent on interaction with other factors such as nutrition, physical activity and environment.
Aim: To determine the prevalence of metabolic syndrome and impact of lifestyle on the CVD risk factors among adult Nigerian with FHD.
Materials and Methods: This was a cross-sectional study among staff and students of Ekiti State University and Ekiti State University Teaching Hospital, Ado-Ekiti, Nigeria. Eighty-six participants with FHD were age and sex-matched with 86 participants who had no FHD. Relevant demographic and lifestyle information were obtained, and clinical measurements of Body Mass Index (BMI), waist and hip circumferences and blood pressures were obtained by standard protocols. Fasting plasma glucose and lipid panel were determined. Metabolic syndrome was defined according to the International Diabetes Federation criteria (IDF). The clinical, laboratory and other variables of the people with FHD and those without FHD were compared with Pearson’s Chi-Square and Student’s t-test.
Results: The age, clinical, anthropometric and laboratory parameters were similar between the two groups. Participants with FHD consume more poultry (17.6% vs 3.5%) and less red meat (27.1% vs 37.2%) than those without FHD (p=0.036), but the level of physical activity and consumption of fruits/vegetables, and smoking did not differ between the two groups. Metabolic syndrome was equally prevalent between the people with or without FHD (p=0.846). There was no significant difference (p>0.05), in the prevalence of CVD risk factors, such as hypertension, hyperglycaemia, dyslipidaemia, and obesity between the two groups.
Conclusion: The prevalence of metabolic syndrome was similar among people with or without FHD. Healthy lifestyle may explain the lack of excess CVD risk factors among people with FHD.
Keywords
Genetics, Metabolic syndrome, Type 2 diabetes
DOI: 10.7860/JCDR/2021/44775.14566
Date of Submission: Apr 24, 2020
Date of Peer Review: Jun 18, 2020
Date of Acceptance: Sep 24, 2020
Date of Publishing: Feb 01, 2021
AUTHOR DECLARATION:
• Financial or Other Competing Interests: None
• Was Ethics Committee Approval obtained for this study? Yes
• Was informed consent obtained from the subjects involved in the study? Yes
• For any images presented appropriate consent has been obtained from the subjects. NA
PLAGIARISM CHECKING METHODS:
• Plagiarism X-checker: Apr 25, 2020
• Manual Googling: Sep 09, 2020
• iThenticate Software: Jan 08, 2021 (17%)
Etymology: Author Origin
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