Membranoproliferative Glomerulonephritis- A Disease or a Pattern of Injury?
Published: November 1, 2020 | DOI: https://doi.org/10.7860/JCDR/2020/45206.14257
Subhrajyoti Karmakar, Keya Basu, Moumita Sengupta, Arpita Roychowdhury, Rajendra Pandey, Manimoy Bandopadhyay
1. Junior Resident, Department of Pathology, IPGME and R, Kolkata, West Bengal, India.
2. Associate Professor, Department of Pathology, IPGME and R, Kolkata, West Bengal, India.
3. Associate Professor, Department of Pathology, IPGME and R, Kolkata, West Bengal, India.
4. Professor, Department of Nephrology, IPGME and R, Kolkata, West Bengal, India.
5. Professor, Department of Nephrology, IPGME and R, Kolkata, West Bengal, India.
6. Professor, Department of Anatomy, IPGME and R, Kolkata, West Bengal, India.
Correspondence Address :
Moumita Sengupta,
Flat No. A11, Snehaneer APT, 1185 Chakgaria, Kolkata, West Bengal, India.
E-mail: moumitasengupta83@gmail.com
Abstract
Introduction: Pre-Eclampsia (PE) is the common multisystem disorder which complicates the pregnancies 3-8% and a major cause of morbidity and mortality throughout the world.
Aim: To determine the correlation of placental growth factor with PE in mid trimester of pregnancy at Liaquat University of Medical and Health Sciences Jamshoro.
Materials and Methods: This Case-Control study was performed at Pathology Department with Department of Obstetrics and Gynaecology, Liaquat University of Medical and Health Sciences (LUMHS) Jamshoro/Hyderabad, during 12 months, from 6th February, 2017 to 5th February 2018. Pregnant women with mid trimester were enrolled in the study. Group A included females with PE, while Group B were normotensive females of same gestation. Their blood sample were collected and stored at -80°. Level of placental growth factor was measured on Elecsys system. Data was analysed via Statistical Package for the Social Sciences (SPSS) version 20.
Results: Total 384 PE females were selected and 50 females without hypertension were studied as control. Mean age of patients was 27.46±3.91 years. No significant variance was seen between mean of gestational age of patients and normal pregnant females; p-value 0.346. Mean of placental growth factor was insignificantly decreased 35.21±31.68 pg/mL among patients in contrast to normal women as 47.23±56.13 pg/mL, p=0.081. A negative correlation was found between blood pressure and placental growth factor, r-values -0.004 and -0.001, respectively.
Conclusion: It was concluded that serum placental growth factor was the poor marker for PE, as it showed weak negative correlation with PE.
Keywords
Immunofluorescence microscopy, Light microscopic, Nephritic syndrome