Membranoproliferative Glomerulonephritis- A Disease or a Pattern of Injury?
EC23-EC27
Correspondence
Moumita Sengupta,
Flat No. A11, Snehaneer APT, 1185 Chakgaria, Kolkata, West Bengal, India.
E-mail: moumitasengupta83@gmail.com
Introduction: Pre-Eclampsia (PE) is the common multisystem disorder which complicates the pregnancies 3-8% and a major cause of morbidity and mortality throughout the world.
Aim: To determine the correlation of placental growth factor with PE in mid trimester of pregnancy at Liaquat University of Medical and Health Sciences Jamshoro.
Materials and Methods: This Case-Control study was performed at Pathology Department with Department of Obstetrics and Gynaecology, Liaquat University of Medical and Health Sciences (LUMHS) Jamshoro/Hyderabad, during 12 months, from 6th February, 2017 to 5th February 2018. Pregnant women with mid trimester were enrolled in the study. Group A included females with PE, while Group B were normotensive females of same gestation. Their blood sample were collected and stored at -80°. Level of placental growth factor was measured on Elecsys system. Data was analysed via Statistical Package for the Social Sciences (SPSS) version 20.
Results: Total 384 PE females were selected and 50 females without hypertension were studied as control. Mean age of patients was 27.46±3.91 years. No significant variance was seen between mean of gestational age of patients and normal pregnant females; p-value 0.346. Mean of placental growth factor was insignificantly decreased 35.21±31.68 pg/mL among patients in contrast to normal women as 47.23±56.13 pg/mL, p=0.081. A negative correlation was found between blood pressure and placental growth factor, r-values -0.004 and -0.001, respectively.
Conclusion: It was concluded that serum placental growth factor was the poor marker for PE, as it showed weak negative correlation with PE.