Evaluation of the Hypoglycaemic and
Hypolipidaemic Activities of the Aqueous Extract of
the leaves of Ixora Coccinea Linn in Diabetic Rats
1381-1384
Correspondence
M.D. Pharmacology, Professor & HOD,
Department of Pharmacology,
S.Nijalingappa Medical College and H.S.K
Hospital and Research Centre, Navanagar,
Bagalkot , Karnataka, India 587101
yasmeenmaniyar@gmail.com
Objective: To evaluate the hypoglycaemic and the hypolipidaemic activity of the aqueous extract of the leaves of Ixora Coccinea Linn in alloxan induced diabetic albino rats.
Materials and methods: Diabetes was induced in the albino rats by the administration of alloxan monohydrate (120 mg/kg, i.p.). The rats were divided into five groups of six animals each. The first group served as the non-diabetic control, the second group as the diabetic control and the third group as the standard and it was treated with 0.1 mg/kg/ day of glibenclamide. Groups four, five and six received 100, 200 and 400 mg/kg body weight of the aqueous extract. The blood samples were analyzed for blood glucose on days 0, 1, 7, 14 and 21 and the lipid profile was assessed on day 21.
Results: The aqueous extract of leaves of Ixora Coccinea showed significant reduction (p<0.01) in the blood glucose levels and the serum lipid profile levels, with 400 mg/kg of body weight in the alloxan induced diabetic rats as compared to the controls.
Conclusion: It was concluded that the aqueous extract of the leaves of Ixora Coccinea was effective in controlling the blood glucose levels and in improving the lipid profile in diabetic rats.