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Role of Cerebro-Placental Ratio in Predicting Adverse Outcomes in Low-Risk Pregnancies- A Prospective Cohort Study
QC05-QC09
Correspondence
Dr. C Kavyarani,
#28, Beereshwara, 4th Cross, Jayanagar, Kolar-563101, Karnataka, India.
E-mail: kavyaranic@gmail.com
Introduction: Abnormal Cerebro-Placental Ratio (CPR) is associated with a substantial risk of adverse perinatal outcomes and the test seems to be particularly useful for follow-up of foetuses with sonographically diagnosed Foetal Growth Restriction (FGR).
Aim: To determine the usefulness of doppler velocimetry, especially CPR at 35 weeks of gestation or later, in predicting intrapartum foetal heart rate abnormalities and adverse neonatal outcomes in low-risk term pregnancies.
Materials and Methods: The present prospective cohort study was conducted at the Department of Obstetrics and Gynaecology in Bangalore Baptist Hospital, Bangalore, India from September 2019 to September 2020. A total of 60 pregnant women between the age group of 18 to 35 years with low-risk pregnancies, who present for the obstetrical ultrasound at 35 weeks of gestation or later with planned delivery at the hospital were included. All low-risk pregnant women with Estimated Foetal Weight (EFW) >10th centile and abnormal Cerebro-Placental Ratio (CPR) <10th centile were compared with those of normal CPR i.e., >10th centile. An adverse obstetric outcome like foetal distress, meconium aspiration syndrome or respiratory distress syndrome, mode of delivery, admission to Neonatal Intensive Care Unit (NICU), and perinatal mortality was analysed in the study population using Chi-square test or Fisher’s-exact test.
Results: In this study, there was a significant association between foetal distress and CPR with Odds Ratio (OR) of 4.21 i.e., foetal distress was 4.21 times higher in the abnormal group compared to the normal group. Among 20 cases with abnormal CPR, 11 had foetal distress i.e., 55% and among 40 cases with normal CPR, nine had foetal distress i.e., 22.5%. Among those with abnormal CPR, 15% had Amniotic Fluid Index (AFI) <8 and among those with normal CPR, 0 had AFI <8, showing a significant association.
Conclusion: In low-risk patients with EFW >10th centile and abnormal CPR, there was a significant association with adverse obstetric outcomes, requiring vigilant intrapartum monitoring.