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Preoperative Nebulisation with Dexmedetomidine to Prevent Postoperative Sore Throat in Patients Undergoing General Anaesthesia
UC55-UC57
Correspondence
Anilin Joey,
Third Year Resident, Department of Anaesthesiology, Dr. D. Y. Patil Medical College, Hospital, Research Centre, Dr. D. Y. Patil Vidyapeeth, Pimpri, Pune-411018, Maharashtra, India.
E-mail: anilinjoey@yahoo.com
Introduction: Several pharmacological and non-pharmacological ways have been used to prevent Postoperative Sore Throat (POST). Postoperative Sore Throat (POST) can be prevented with or without medical management. Dexmedetomidine is a selective alpha 2 adrenergic agonists which can be used for preoperative nebulisation to prevent POST. Dexmedetomidine absorption will be greater through transmucosal route as it is a highly lipid soluble agent. It is a highly lipid soluble agent with good systemic absorption during transmucosal administration.
Aim: To assess the efficacy of dexmedetomidine nebulisation in reducing POST in patient who require general anaesthesia with endotracheal intubation.
Materials and Methods: This randomised control study was conducted from January 2022 to March 2022. There were 60 patients separated into two groups and 30 patients in each. The patients were of age more than 18 years and belonged to American Society of Anaesthesiology (ASA) grade I and II, posted for elective surgery under general anaesthesia. Group D was given dexmedetomidine 50 mcg (1 mL) with 3 mL of saline and made it total volume of 4 mL nebulisation and Group C was given 4 mL of saline nebulisation. Sore throat was evaluated at 0, 2nd,4th,6th,12th and 24th hour after extubation, during the postoperative period. The recorded data was analysed using the Statistical Package for Social Sciences (SPSS), 21 version.
Results: Mean age (SD) of patients in group D was 33.5±12.9 years and that in group C was 36.83±14.5 years (p-value=0.23). During postoperative period, the severeness of sore throat was remarkably lesser in Group D especially from 4th hour upto 24th hour. Severeness of POST was remarkably lesser in group D compared to group C patients over the 4th-24th hours.
Conclusion: Dexmedetomidine nebulisation given prior to surgery is beneficial in reducing POST, with minimal haemodynamic disturbance. Dexmedetomidine in nebulised form is therefore a safe option for lowering POST.