Development of the Human Lymph Nodes- A Histological Study
1155-1157
Correspondence
Dr. Aksh Dubey,
Department of Anatomy,
Himalayan Institute of Medical Sciences,
Dehradun Uttarakhand, 248140, India.
Phone: 9456308611
E-mail: dubey.anatomy@gmail.com
Background: A lymph node is a large accumulation of lymphatic tissue organized as a definite lymphatic organ. Such nodes are located along the course of lymphatic vessels.
Objectives: The aim of present study was to study the developmental histology of lymph nodes in human fetuses of different gestational ages.
Methods: Fetuses were divided into five groups according to different gestational ages. Axillary lymph nodes were procured, fixed, processed and stained with Heamatoxylin and Eosin.
Results: Lymphatic sacs and lymphatic vessels developed around blood vessels. The lymphatic vessels interlaced with each other. Later on lymphocytic infilteration occurred and lymph nodes formed. Later, increase in size and number of lymphocytes converted these nodes into mature lymph nodes.
Interpretation and conclusion: The human lymph nodes developed from infiltration of lymphatic sacs and lymphatic vessels by lymphocytes. The subcapsular sinus appeared during the gestational period from week 15 to 17 and corticomedullary differentiation took place from week 25 to 38.