Antioxidant Enzymes And Vitamins In Gestational Diabetes.
1081-1085
Correspondence
Surapaneni Krishna Mohan,Assistant Professor, Department of Biochemistry, Saveetha Medical College & Hospital, Saveetha University,Chennai – 600 077, India.krishnamohan_surapaneni@yahoo.com
The exact pro-oxidant and antioxidant status in gestational diabetes is still not clear. To add a new insight to the question, levels of erythrocyte antioxidant vitamin Ascorbic acid and plasma vitamin E (non enzymatic antioxidant vitamin parameters) and activities of antioxidant enzymes Super Oxide Dismutase (SOD), Glutathione Peroxidase (GPX) and Catalase in erythrocytes were studied in patients with gestational diabetes and compared to controls. Statistical analysis between controls and patients was performed by Mann Whitney U test using stat - view package. It was observed that there was a significant increase in activities of SOD, GPX and a significant decrease in erythrocyte ascorbic acid, plasma vitamin E levels and Catalase activity in patients with gestational diabetes when compared to controls. Results of our study depict higher oxygen free radical production, evidenced by increased levels of MDA and decreased levels of GSH, ascorbic acid, vitamin E and Catalase activity, supporting the evidence of oxidative stress in gestational diabetes patients. Increased activities of antioxidant enzymes might be a compensatory regulation of body in response to increased oxidative stress. Decreased concentrations of antioxidant vitamins support the hypothesis that gestational diabetes is an important causative factor in pathogenesis of lipid peroxidation. These data reveal that antioxidant defense mechanisms might be impaired in patients with gestational diabetes. These findings also provide a theoretical basis for development of novel therapeutic strategies, such as antioxidant supplementation.