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Valproate Induced Hyperammonemic Delirium
FR01-FR03
Correspondence
Dr. Dhanya Sasidharan Palappallil,
Assistant Professor, Department of Pharmacology, Government TDMCA, Kerala-688005, India.
E-mail: drspdhanya@gmail.com
Sodium valproate induced hyperammonaemic delirium with normal liver function tests is a relatively uncommon adverse effect. It may be mistaken for psychosis or worsening of mania leading to wrong diagnosis and improper management. Plasma ammonia levels should be monitored in all patients developing altered mental status after receiving valproate therapy. This is a case series of hyperammonaemic delirium due to valproate reported to the Department of Pharmacology from Department of Psychiatry over a period of one year.