Columnar Cell Lesions of the Breast –Significant or Not? 239-242
Rajalakshmi T, Assistant Professor Department of Pathology, St. Johnâ€™s Medical College, Bangalore â€“ 560 034. India. Email: firstname.lastname@example.org
Columnar cell lesions (CCLs) of the breast range from the innocuous CAPSS (columnar alteration with prominent apical snouts and secretions) to DCIS. Their precancerous potential poses diagnostic and therapeutic riddles, especially in those which show mammographic microcalcifications.
1. To document the prevalence of CCLs in the breast.
2. To study their morphologic spectrum.
3. To study the significance of their association with benign and malignant breast lesions.
Material and Methods:One hundred consecutive breast specimens were studied. These specimens included biopsies, lumpectomies and mastectomies. CCLs were classified as per Schnitt criteria. Associated lesions in the adjacent tissue were studied.
Results: Of the 100 samples (43 malignant and 57 benign), 37 cases showed CCL: CAPSS â€“ 23, columnar cell hyperplasia â€“ 11 and columnar cell hyperplasia with atypia â€“ three. The commonest associated lesion was fibrocystic change (n = 54). Their incidence in benign and malignant lesions was 42% and 30%, respectively, with no statistical significance in the difference. Lesions with atypia were seen only in malignant cases.
Conclusions:CCLs are common and often overlooked. These lesions are seen in association with both benign and malignant breast lesions. It is only the presence of atypia in CCL that warrants a special mention and necessitates follow-up, and resection if indicated.