Influence of Helicteres isora Bark Extracts on Plasma and Tissue Glycoprotein Components in Streptozotocin Diabetic Rats 330-338
Dr. G. Kumar. Head and Senior Lecturer in Biochemistry, Selvamm Arts and Science College, Namakkal (DT)-637003, Tamilnadu, India. Tel.: +91-(0) 4286-244606 E-mail: firstname.lastname@example.org
Background: The present study investigated the effect of aqueous bark extracts of Helicteres isora on dearrangement in glycoprotein levels in the streptozotocin-induced diabetic rats.
Materials and Methods: The bark extracts of H. isora (100, 200 mg/kg) was administered orally for 30 days to normal and diabetic rats. The effect of bark extracts on glucose, insulin, and plasma and tissue glycoproteins were studied. The effect of bark extract was compared with tolbutamide, a reference drug.
Result: The levels of glucose, glycosylated haemoglobin and plasma glycoproteins containing hexose, hexosamine and fucose were increased significantly, whereas the level of plasma insulin and haemoglobin were decreased significantly in diabetic rats. There was a significant decrease in the level of sialic acid and elevated levels of hexose, hexosamine and fucose in the liver and kidney of streptozotocin-diabetic rats. Administration of H. isora (100, 200 mg/kg) to diabetic rats was followed by a decreased level of glucose, glyosylated haemoglobin and plasma glycoproteins. The levels of plasma insulin, haemoglobin and tissue sialic acid were increased, whereas the levels of tissue hexose, hexosamine and fucose were near normal.
Conclusion: The present study indicates that the bark extract of H. isora possesses a significantly beneficial effect on the glycoprotein moiety in addition to its anti-diabetic effect.