Biochemical Changes in Patients with Asthma
Dr Amina Hamed Ahmad Al Obaidi Department of Biochemistry,Medical CollegeTikrit University, Email: firstname.lastname@example.org
Background: The changes that occur in diseases in chemical constituents and biochemical mechanisms are of vital importance for homeostasis within the human body.
Aim: The study was performed on asthmatic patients and healthy non asthmatic control subjects to determine the changes in serum levels of some biochemicals in asthma.
Setting and design:A cross â€“ sectional study with matched control.
Methods and materials: A total of 178 sera were used for determination of iron, calcium, very low density lipoprotein (VLDL), lactate dehydrogenase (LDH) and creatine kinase (CK) . The effect of Immunotherapy on serum iron, calcium, VLDL, LDH and CK was evaluated in 169 asthmatic patients after one year of hyposensitization. All the above were determined using a commercial kits and procedures were performed according to manufacturer instructions.
Statistical analysis:Student t test was used to determined the significance of differences.
Results: The iron and calcium serum levels were significantly lower in stable asthmatic group as compared to that in exacerbation asthmatic . Also, serum iron and calcium levels during asthma exacerbation were significantly higher than that in control. Very low density lipoprotein serum level in stable asthmatic patients was significantly higher (P<0.02) than that of asthmatic patients with exacerbation, but it was lower than that in control (P<0.05). Iron, calcium , LDH, and CK serum levels were significantly reduced following vaccination. However, serum VLDL was significantly higher following immunotherapy as compared to that before vaccination.
Conclusions: Serum iron, calcium levels were higher during asthma exacerbation than in stable asthma and control, while VLDL serum level was lower. Immunotherapy for one year reduce serum iron, LDH, CK and calcium levels and increased VLDL serum level.