Cholesterol-Lowering Activity of the Aqueous Fruit Extract of Trichosanthes dioica Roxb (L.) in Normal and Streptozotocin Diabetic Rats
Mrs. Sharmila Banu G, Lecturer, Biotechnology, Muthayammal College of Arts and Science, Rasipuram, Namakkal 627408, Tamilnadu, India.
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Background: The purpose of this study was to examine the effects of single and repeated oral administration of the aqueous fruit extract of Trichosanthes dioica (TD) at a dose of 50 ml/kg b.w in normal and streptozotocin-induced diabetic rats.
Material-Methods: The aqueous fruit extracts of TD (50 ml/kg) were administered orally for 15 days, to normal and diabetic rats. The effect of the fruit extracts on cholesterol and triglycerides, were studied. The body weights of the rats were observed. The effect of the fruit extract was compared with vanadate, a reference drug.
Result: In normal rats, the aqueous fruit extract of TD induced significant decrease of plasma cholesterol and triglyceride concentrations 6hrs after a single oral administration (P< 0.05), and also in 2 weeks after repeated oral administrations (p< 0.05). TD treatment caused significant decrease of plasma cholesterol levels after a single administration (p<0.01), and after repeated (p<0.01) oral administrations. Significant increase of triglyceride levels was observed 6hrs after a single oral administration of the TD aqueous fruit extract (p< 0.01). One week after repeated oral administration of aqueous extract of TD, the plasma triglyceride levels were significantly decreased (p <0.005). The decreasing trend continued even after 2 weeks (p <0.01). On the other hand, repeated oral administration of TD aqueous fruit extract, caused significant decrease of body weight after 2 weeks of treatment in both normal (p <0.001) and diabetic (p <0.01) rats.
Conclusion: The present study indicates that the aqueous fruit extract of TD exhibits cholesterol and body weight-lowering activities in both normal and hyperglycaemic rats.